Anti-CNDP2 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Mouse
Recombinant Mouse CNDP2 protein (Catalog#50246-M08B)
Produced in rabbits immunized with purified, recombinant Mouse CNDP2 (rM CNDP2; Catalog#50246-M08B; NP_075638.2; Met 1-Asn 475). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CNDP2 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CNDP2 Antibody Alternative Names
Anti-0610010E05Rik Antibody;Anti-C76600 Antibody;Anti-Cn2 Antibody;Anti-Dip-2 Antibody;Anti-Pep-1 Antibody;Anti-Pep1 Antibody
CNDP2 Background Information
Cytosolic non-specific dipeptidase, also known as CNDP dipeptidase 2, Glutamate carboxypeptidase-like protein 1, Peptidase A, CNDP2 and CN2, is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 / CPGL is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 / CPGL hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. It may be play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells. Isoform 1 of CNDP2 / CPGL is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 of CNDP2 / CPGL is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 / CPGL is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis.
CNDP dipeptidase 2 (metallopeptidase M20 family)
Bakker,SJ. et al., 2008, Diabetes 57 (12):e16; author reply e17. Wanic, K. et al., 2008, Diabetes 57 (9): 2547-51. McDonough,CW. et al., 2009, Hum Genet 126 (2): 265-75. Kaur,H. et al., 2009, J Biol Chem. 284 (21):14493-502.