CNDP1 Antibody

CNDP1 Antibody Datasheet

CNDP1 Antibody Product Information

• Immunogen: Recombinant Human CNDP1 Protein (Catalog#10077-H08H)
• Antibody Type: Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform )
• Clone ID: 001
• Ig Type: Rabbit IgG
• Formulation: 0.2 μm filtered solution in PBS with 5% trehalose
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human CNDP1 (rh CNDP1; Catalog#10077-H08H; NP_116038.4; Ser 27-His 508).

CNDP1 Antibody Usage Guide

• Specificity: Human CNDP1
• Direct ELISA: This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CNDP1. The detection limit for Human CNDP1 is approximately 0.0049 ng/well.
• Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
  Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

CNDP1 Antibody Background

CNDP1, also known as glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), is a member of the M20 metalloprotease family. This protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. The CN1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region, which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy, for carnosine protects against the adverse effects of high glucose levels on renal cells. In addition, this enzyme is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.

References

1. Teufel, Mm. et al., 2004, J. Biol. Chem. 278: 6521-6532.
2. Riedl, E. et al., 2007, Diabetes. 56: 2410-2413.
3. Sauerhofer, S. et al., 2007, Diabetes. 56: 2425-2432.