Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb, Antigen Affinity Purified

Cat: 10202-RP02
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All CMV Glycoprotein B Reagents
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb, Antigen Affinity Purified (Rabbit Polyclonal antibody) General Information
Product name
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb, Antigen Affinity Purified
Validated applications
ELISA (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
Specificity
CMV CMV Glycoprotein B
Immunogen
Recombinant Human CMV gB / Glycoprotein B protein (Catalog#10202-VCCH1)
Preparation
Produced in rabbits immunized with purified, recombinant Human CMV gB (Catalog#10202-VCCH1; AAA45920.1) extracellular domain (Met 1-Lys 700) linked with the cytoplasmic domain (Arg 777-Val 907). Human cytomegalovirus gB specific IgG was purified by Human CMV gB affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb, Antigen Affinity Purified (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

CMV Glycoprotein B Background Information

Cytomegalovirus (CMV) (human herpesvirus 5) glycoprotein B, also referred as CMV gB or gB, which belongs to the herpesviridae glycoprotein B family. It is a 907-amino acid glycoprotein encoded by the ORF of UL55. Cytomegalovirus Glycoprotein B protein is the most abundant component of the envelope, a target of neutralizing antibodies with at least two defined neutralizing epitopes and an essential replication component. Cytomegalovirus Glycoprotein B protein plays important roles in HCMV entry, cell-cell spread of internal virions, and fusion of infected cells. In addition, Cytomegalovirus Glycoprotein B protein is one envelope protein capable of heparin binding. It forms a physical association with host cell annexin II independent of the presence of calcium.

References
  • Lopper M,et al. (2002). Disulfide bond configuration of human cytomegalovirus glycoprotein B. J Virol. 76(12): 6073-82.
  • Isaacson MK, et al. (2009) Human cytomegalovirus glycoprotein B is required for virus entry and cell-to-cell spread but not for virion attachment, assembly, or egress. J Virol. 83(8): 3891-903.
  • Product Description Host Clonality Application Catalog# (PDF)
    Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Mouse MAb Mouse Monoclonal WB,ELISA,IHC-P,FCM,ICC/IF,IF,IP 10202-MM02
    Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit MAb Rabbit Monoclonal WB,ELISA,IHC-P,FCM,ICC/IF,IF,IP 10202-R038
    Human cytomegalovirus (HCMV) Glycoprotein B / gB Antibody, Rabbit PAb Rabbit Polyclonal ELISA,IHC-P,FCM,ICC/IF,IF,IP 10202-RP01
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