CLP1 (COLEC12)

CLP1, also known as COLEC12, is a scavenger receptor that displays several functions associated with host defense. It contains 1 C-type lectin domain and 3 collagen-like domains. CLP1 is strongly expressed in placenta and moderately expressed in heart, skeletal muscle, small intestine and lung. It promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. It binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. It binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.

CLP1 (COLEC12) Related Areas

Immunology>>Innate Immunity>>Monocyte/Macrophage>> CLP1 / COLEC12

CLP1 (COLEC12) Alternative Names

CLP1, NSR2, SCARA4, SRCL, collectin placenta protein 1, collectin-12, hCL-P1, nurse cell scavenger receptor 2, scavenger receptor class A, member 4, scavenger receptor with C-type lectin [Homo sapiens]

CL-P1, SRCL, Scara4, collectin placenta protein 1, collectin-12, scavenger receptor with C-type lectin [Mus musculus]

Human CLP1 (COLEC12) Protein General Information

 

• Protein names: Collectin placenta protein 1, Short name=CL-P1
• Sequence length: 742 AA.
• Sequence similarities: CLP1 contains 1 C-type lectin domain. CLP1 contains 3 collagen-like domains.
• Subunit structure: The extracellular domain forms a stable trimer. The extracellular domain interacts with fibrillar beta amyloid peptide.
• Subcellular location: Membrane; Single-pass type II membrane protein. Note: Forms clusters on the cell surface.
• Tissue specificity: CLP1 is expressed in perivascular macrophages. CLP1 is expressed in plaques-surrounding reactive astrocytes and in perivascular astrocytes associated with cerebral amyloid angiopathy (CAA) in the temporal cortex of Alzheimer patient (at protein level). CLP1 is strongly expressed in placenta. Moderately expressed in heart, skeletal muscle, small intestine and lung. CLP1 is weakly expressed in brain, colon, thymus and kidney. CLP1 is expressed in nurse-like cells. CLP1 is expressed in reactive astrocytes and vascular/perivascular cells in the brain of Alzheimer patient.
• Sequence caution: The sequence BAB39148.1 differs from that shown. Reason: Probable cloning artifact.

General information above from UniProt

Function for CLP1 (COLEC12) Protein

UniProtKB:

CLP1 is scavenger receptor that displays several functions associated with host defense. CLP1 promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. CLP1 mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. CLP1 binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. CLP1 binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). CLP1 may also play a role in the clearance of amyloid beta in Alzheimer disease.

Genatlas:

• CLP1 is involved in the cleavage of the pre-mRNA

Homology for human CLP1 (COLEC12)

• homolog to C.elegans ATP-GTP binding protein (putative)