CLM-9 Protein, Human, Recombinant (Fc Tag)

Cat: 13365-H02H
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CLM-9 Protein, Human, Recombinant (Fc Tag) Product Information
Purity
(74+24.5) % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the human CD300LG (AAH25395.1) (Met1-Arg247) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
GenBank#
Expressed Host
HEK293 Cells
Species
Human
Predicted N Terminal
Leu 19
Molecule Mass
The recombinant human CD300LG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 470 amino acids and has a predicted molecular mass of 51.7 kDa. The apparent molecular mass of the protein is approximately 70 and 34 kDa in SDS-PAGE under reducing conditions.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
CLM-9 Protein, Human, Recombinant (Fc Tag) in SDS-PAGE
Human CLM-9 / TREM4 Protein 10301
CLM-9 Protein, Human, Recombinant (Fc Tag) Alternative Names
CLM-9 Protein, Human;CLM9 Protein, Human;NEPMUCIN Protein, Human;TREM-4 Protein, Human;TREM4 Protein, Human
CLM-9 Background Information

CLM-9, also known as TREM4, is a receptor which belongs to the TREM family. The TREM family of receptors regulates the activity of various cell types of the immune system including neutrophils, monocyte/macrophages, microglia, and dendritic cells. CLM-9 may mediate L-selectin-dependent lymphocyte rollings. It binds SELL in a calcium dependent manner. CLM-9 also binds lymphocyte which suggests that it functions in lymphocyte adhesion. The major CLM-9 transcript is expressed highly in human heart, skeletal muscle, and placenta. The mouse protein has been shown to be expressed in capillary endothelial cells. Human CLM-9 mediates the uptake of human IgA2 and mouse IgM.

Full Name
CD300 molecule-like family member g
References
  • Clark GJ, et al. (2009) The CD300 molecules regulate monocyte and dendritic cell functions. Immunobiology. 214(9-10):730-6.
  • Engel K, et al. (2012) Bacterial expression of mutant argininosuccinate lyase reveals imperfect correlation of in-vitro enzyme activity with clinical phenotype in argininosuccinic aciduria. J Inherit Metab Dis. 35(1):133-40.
  • Lamesch P, et al. (2007) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Genomics. 89(3):307-15.
  • Other CLM-9 Proteins

    Rat CLM-9 Proteins

    Product Name Cat.No.
    CLM-9 Protein, Rat, Recombinant (His Tag) 80413-R08H

    Human CLM-9 Proteins

    Product Name Cat.No.
    CLM-9 Protein, Human, Recombinant (His Tag) 13365-H08H
    CLM-9 Protein, Human, Recombinant 13365-HCCH
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