CLIC4 cDNA ORF Clone in Cloning Vector, Human

Cat: HG12271-G
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CLIC4 cDNA ORF Clone in Cloning Vector, Human General Information
Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
762 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human chloride intracellular channel 4.
Plasmid
Vector
pGEM-T Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.
CLIC4 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

CLIC4 cDNA ORF Clone in Cloning Vector, Human Alternative Names
CLIC4L cDNA ORF Clone, Human;H1 cDNA ORF Clone, Human;huH1 cDNA ORF Clone, Human;MTCLIC cDNA ORF Clone, Human;p64H1 cDNA ORF Clone, Human
CLIC4 Background Information

Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains one GST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.

Full Name
chloride intracellular channel 4
References
  • Ronnov-Jessen L., et al., 2002, Am. J. Pathol. 161:471-480.
  • Berryman M.A., et al., 2003, Cell Motil. Cytoskeleton 56:159-172.
  • Suh,K.S. et al., 2005, J Investig Dermatol Symp Proc. 10 (2):105-9.
  • Suh,K.S. et al., 2007, Mol Carcinog.46 (8):599-604.
  • Suh,K.S. et al., 2007, J Cell Sci  120 (Pt 15):2631-40.
  • Suh,K.S. et al., 2007, Clin Cancer Res  13 (1):121-31.
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