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CLIC4 Antibody, Rabbit PAb, Antigen Affinity Purified

  • CLIC4 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • CLIC4 Antibody, Rabbit PAb, Antigen Affinity Purified
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Human CLIC4 Antibody Product Information
Immunogen:Recombinant Human CLIC4 protein (Catalog#12271-H07E)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Human CLIC4 (rh CLIC4; Catalog#12271-H07E; Q9Y696-1; Ala 2-Lys 253). CLIC4 specific IgG was purified by Human CLIC4 affinity chromatography.
Human CLIC4 Antibody WB Application Image
Human CLIC4 Antibody IP Application Image
Other CLIC4 Antibody Products

Anti-Histone H3 rabbit monoclonal antibody at 1:200 dilution

Lane A: NIH3T3 Whole Cell Lysate

Lane B: Hela Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution.

Developed using the ECL technique.

Performed under reducing conditions.

Predicted band size:15 kDa

Observed band size:17 kDa

CLIC4 Background

Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains one GST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. CLIC4 could promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Expression of CLIC4 is prominent in heart, kidney, placenta and skeletal muscle. Overexpression of CLIC4 in cancer cells inhibits tumor growth. Conversely, overexpression of CLIC4 in tumor stromal cells stimulates tumor growth. Thus, CLIC4 participates in normal and pathological processes and may serve as a useful target for therapies in disturbances of homeostasis and neoplastic transformation. Loss of CLIC4 in tumor cells and gain in tumor stroma is common to many human cancers and marks malignant progression. Up-regulation of CLIC4 in tumor stroma is coincident with myofibroblast conversion, generally a poor prognostic indicator. Reactivation and restoration of CLIC4 in tumor cells or the converse in tumor stromal cells could provide a novel approach to inhibit tumor growth.

Human CLIC4 References
  • Ronnov-Jessen L., et al., 2002, Am. J. Pathol. 161:471-480.
  • Berryman M.A., et al., 2003, Cell Motil. Cytoskeleton 56:159-172.
  • Suh,K.S. et al., 2005, J Investig Dermatol Symp Proc. 10 (2):105-9.
  • Suh,K.S. et al., 2007, Mol Carcinog.46 (8):599-604.
  • Suh,K.S. et al., 2007, J Cell Sci  120 (Pt 15):2631-40.
  • Suh,K.S. et al., 2007, Clin Cancer Res  13 (1):121-31.
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