CLEC4N Protein & Antibody (Nkcl)

C-type lectin domain family 4, member n (Natural killer complex lectin)

CLEC4N Products

CLEC4N Protein, Recombinant

Molecule	Species	Description	Cat. No
CLEC4N/Nkcl	Mouse	CLEC4N/Nkcl Protein, Recombinant	50267-M08H

  50267-M08H: Mouse CLEC4N at 25 µg/ml could agglutinate 1 % HRBC. Measured by its ability to agglutinate human red blood cells.

CLEC4N Antibody

Molecule	Application	Description	Cat. No
Mouse CLEC4N/Nkcl	WB, ELISA	CLEC4N/Nkcl Antibody, Rabbit MAb	50267-R001
Mouse CLEC4N/Nkcl	WB, ELISA	Rabbit Polyclonal Antibody	50267-RP01
Mouse CLEC4N/Nkcl	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	50267-RP02

CLEC4N cDNA Clone

Molecule	Species	Description	Cat. No
CLEC4N/Nkcl	Mouse	Mus musculus CLEC4N/Nkcl cDNA Clone	MG50267-M

CLEC4N Related Areas

Immunology>>Adhesion Molecule>>Lectin>>CLEC4N / Nkcl

CLEC4N Alternative Names

Clec4n, Nkcl, Clecsf10, dectin-2 [Mus musculus]

CLEC4N Background

C-type lectin domain family 4 member N (CLEC4N), also known as Dectin-2, is a C-type lectin expressed by dendritic cells (DCs) and macrophages. Members of the C-type lectin domain (CTLD) superfamily are metazoan proteins functionally important in glycoprotein metabolism, mechanisms of multicellular integration and immunity. They share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp family was essentially formed early in vertebrate evolution and is completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates. Dectin-2 is important in host defense against C. albicans by inducing Th17 cell differentiation. Dectin-2 constitutes a major fungal pattern recognition receptor (PRR) that can couple to the Syk-CARD9 innate signaling pathway to activate DCs and regulate adaptive immune responses to fungal infection.

CLEC4N Related Studies

1. Robinson MJ, et al. (2009) Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. J Exp Med. 206(9): 2037-51.
2. Saijo S, et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 32(5): 681-91.