Anti-CLEC-2 Antibody

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Anti-CLEC-2 Antibody (Rabbit Monoclonal antibody) General Information

Product name
Anti-CLEC-2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CLEC-2
Immunogen
Recombinant Human CLEC1B / CLEC2 Protein (Catalog#10976-H07H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CLEC1B / CLEC2 (rh CLEC1B / CLEC2; Catalog#10976-H07H; Gln 58-Pro 229; NP_057593.3).
Source
Monoclonal Rabbit IgG Clone #004
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CLEC-2 Antibody (Rabbit Monoclonal antibody) Validated Applications

Application Dilution
ELISA 1:5000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-CLEC-2 Antibody: Alternative Names

Anti-1810061I13Rik Antibody; Anti-CLEC2 Antibody; Anti-CLEC2B Antibody; Anti-PRO1384 Antibody; Anti-QDED721 Antibody

CLEC-2 Background Information

CLEC1B, also known as CLEC2, is a C-type lectin-like receptor expressed in myeloid cells and NK cells. Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 and NKG2D, that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. CLEC2 contains 1 C-type lectin domain and is expressed preferentially in the liver. It acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Full Name
C-type lectin domain family 1, member B
References
  • Suzuki-Inoue K, et al. (2007) Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. J Biol Chem. 282(36):25993-6001.
  • Watson AA, et al. (2007) The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2. J Biol Chem. 282(5):3165-72.
  • Chaipan C, et al. (2006) DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets. J Virol. 80(18):8951-60.
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