CLEC1A (CLEC-1)

CLEC1A, also known as CLEC-1, is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. CLEC1A contains 1 C-type lectin domain and is expressed preferentially in dendritic cells. It may play a role in regulating dendritic cell function. CLEC1A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splice variants have been described but their biological nature has not been determined. CLEC1A is found to be not only expressed in dendritic cells, but also in endothelial cells and in the latter aspect resembles the LOX-1 gene.

CLEC1A (CLEC-1) Related Areas

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>CD302/CLEC13A

Immunology>>Adhesion Molecule>>Lectin>>CD302/CLEC13A

CLEC1A (CLEC-1) Alternative Names

UNQ569/PRO1131, CLEC1, MGC34328, C-type lectin domain family 1 member A, C-type lectin-like [Homo sapiens]

5930406N14Rik, C-type lectin domain family 1 member A [Mus musculus]

Summaries for CLEC1A (CLEC-1)

Entrez Gene summary for CLEC1A (CLEC-1):

CLEC1A gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. CLEC1A gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]

OMIM - description for CLEC1A (CLEC-1):

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; 602894) and NKG2D (KLRC4; 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC1 is a C-type lectin-like receptor expressed in dendritic cells (Colonna et al., 2000).

Wikipedia summary for CLEC1A (CLEC-1):

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Human CLEC1A (CLEC-1) Protein General Information

 

• Protein names: C-type lectin-like receptor 1
  Short name=CLEC-1
  Short name=CLEC1A
• Sequence length: 280 AA.
• Domain: Signal-anchor
  Transmembrane
  Transmembrane helix
• Sequence similarities: Contains 1 C-type lectin domain.
• Subcellular location: Membrane; Single-pass type II membrane protein
• Tissue specificity: Expressed preferentially in dendritic cells.

General information above from UniProt

Function for CLEC1A (CLEC-1) Protein

Genatlas:

• CLEC1A plays a role in regulating dendritic cell function