CLEC14A Protein & Antibody

C-type lectin domain family 14, member a

CLEC14A Products

CLEC14A Protein, Recombinant

Molecule	Species	Description	Cat. No
CLEC14A	Mouse	CLEC14A Protein, Recombinant	50304-M08H

CLEC14A Antibody

Molecule	Application	Description	Cat. No
Mouse CLEC14A	WB, ELISA	CLEC14A Antibody, Rabbit PAb	50304-RP01
Mouse CLEC14A	WB, ELISA	CLEC14A Antibody, Rabbit PAb (Antigen Affinity Purified)	50304-RP02

CLEC14A cDNA Clone

Molecule	Species	Description	Cat. No
Rat CLEC14A	Rat	CLEC14A cDNA Clone	RG80211-G

CLEC14A Related Areas

Immunology>>Adhesion Molecule>>Lectin>>CLEC14A

CLEC14A Alternative Names

CLEC14A, C14orf27, CEG1 [Homo sapiens]

Clec14a, 1200003C23Rik, AI642649 [Mus musculus]

CLEC14A Background

C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a 459 amino acid single-pass type I membrane protein. The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop ('loop-in-a-loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. Members of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates.

CLEC14A Related Studies

1. Ebner S, et al. (2003) Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins. 53(1): 44-55.
2. Zelensky AN, et al. (2005) The C-type lectin-like domain superfamily. Gready JE. FEBS J. 272(24): 6179-217.