Anti-CLEC14A Antibody

Cat: 50304-RP02
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Anti-CLEC14A Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CLEC14A Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CLEC14A
Immunogen
Recombinant Mouse CLEC14A protein (Catalog#50304-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CLEC14A (Catalog#50304-M08H; NP_080085.3; Met 1-Thr 386). CLEC14A specific IgG was purified by human CLEC14A affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CLEC14A Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CLEC14A Antibody Alternative Names
Anti-1200003C23Rik Antibody;Anti-AI642649 Antibody
CLEC14A Background Information

C-type lectin domain family 14 member A, also known as Epidermal growth factor receptor 5 and CLEC14A, is a member of the C-type lectin domain (CTLD) family that contains one c-type lectin domain and one EGF-like domain. Mouse CLEC14A is a 459 amino acid single-pass type I membrane protein. The superfamily of proteins containing C-type lectin-like domains (CTLDs) is a large group of extracellular Metazoan proteins with diverse functions. The CTLD structure has a characteristic double-loop ('loop-in-a-loop') stabilized by two highly conserved disulfide bridges located at the bases of the loops, as well as a set of conserved hydrophobic and polar interactions. Members of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily share a common fold and are involved in a variety of functions, such as generalized defense mechanisms against foreign agents, discrimination between healthy and pathogen-infected cells, and endocytosis and blood coagulation. Genome-level studies on human, elegans and melanogaster demonstrated almost complete divergence among invertebrate and mammalian families of CTLD-containing proteins (CTLDcps). The vertebrate CTLDcp families were essentially formed early in vertebrate evolution and are completely different from the invertebrate families. The composition of the CTLDcp superfamily in fish and mammals suggests that large scale duplication events played an important role in the evolution of vertebrates.

Full Name
C-type lectin domain family 14, member A
References
  • Ebner S, et al. (2003) Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily. Proteins. 53(1): 44-55.
  • Zelensky AN, et al. (2005) The C-type lectin-like domain superfamily. Gready JE. FEBS J. 272(24): 6179-217.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CLEC14A Antibody Rabbit Monoclonal ELISA 50304-R036
    Anti-CLEC14A Antibody Rabbit Polyclonal ELISA 50304-T16
    Anti-CLEC14A Antibody Rabbit Polyclonal ELISA 50304-RP01
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