Mouse CLEC10A / MGL1 Protein

C-type lectin domain family 10, member A Protein Datasheet

CLEC10A / MGL1 / / C-type lectin domain family 10, member A Protein Product Information

• Synonym: Clec10a,DN-160I24.1, CD301a, M-ASGP-BP-1, Mgl, Mgl1
• Protein Construction: A DNA sequence encoding the extracellular domain of mouse CLEC10A (NP_001191181.1) (Gln 58-Ser 305) was fused with the Fc region of human IgG1 at the N-terminus.
• Source: Mouse
• Expression Host: Human Cells

CLEC10A / MGL1 / / C-type lectin domain family 10, member A Protein QC Testing

• Purity: > 86 % as determined by SDS-PAGE.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Glu
• Molecular Mass: The recombinant mouse CLEC10A/Fc is a disulfide-linked homodimer. The reduced monomer comprises 508 amino acids and predicts a molecular mass of 56.7 kDa. The apparent molecular mass of the monomer is approximately 58 kDa in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS , pH 7.4
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: CLEC10A / MGL1 / / C-type lectin domain family 10, member A protein

CLEC10A / MGL1 / / C-type lectin domain family 10, member A Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLEC10A / MGL1 / / C-type lectin domain family 10, member A Protein Description

Lecticans are a family of chondroitin sulfate proteoglycans including aggrecan, versican, neurocan, and brevican. C-type lectin domain family 10 member A also known as CLEC10A is a member of the C-type lectin/C-type lectin-like domain superfamily. Members of this family share a common protein fold and have diverse functions, including cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. C-type lectin-like domains associate with each other through several different surfaces to form dimers and trimers, from which ligand-binding sites project in a variety of different orientations.

References

1. Aspberg A, et al. (1997) PNAS .94 (19): 10116-21.
2. Kurt Drickamer. (1999) Current Opinion in Structural Biology. 9(5): 585-90.
3. Suzuki N, et al. (1996) The Journal of Immunology. 156(1) :128-35.