CLDN11 (Claudin-11)

Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions.Claudin-11 is a tight junction associated protein and is a major component of central nervous system (CNS) myelin that is necessary for normal CNS function. Human blood-testis barrier disruption is related to a dysfunction of CLDN11 gene. It plays an important role in regulating proliferation and migration of oligodendrocytes.

CLDN11 (Claudin-11) Related Areas

 

CLDN11 (Claudin-11) Alternative Names

OSP, OTM, claudin-11, oligodendrocyte transmembrane protein, oligodendrocyte-specific protein [Homo sapiens]

Claudin-11, Claudin11, Osp, Otm, claudin-11, oligodendrocyte transmembrane protein, oligodendrocyte-specific protein [Mus musculus]

Summaries for CLDN11 (Claudin-11)

Entrez Gene summary for CLDN11:

This CLDN11 gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this CLDN11 gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]

Wikipedia summary for CLDN11:

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. It belongs to the group of claudins.
The protein encoded by this CLDN11 gene belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, CLDN11 is a candidate autoantigen in the development of autoimmune demyelinating disease.

Human CLDN11 (Claudin-11) Protein General Information

 

• Protein names: Claudin-11
• Sequence length: 207 AA.
• Sequence similarities: CLDN11 belongs to the claudin family.
• Subunit structure: CLDN11 interacts with tetraspanin-3/TSPAN3
• Subcellular location: Cell junction › tight junction. Cell membrane; Multi-pass membrane protein.

General information above from UniProt

Function for CLDN11 (Claudin-11) Protein

UniProtKB:

CLDN11 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity

Genatlas:

• CLDN11 is tight junction specific obliteration of the intercelular space
• CLDN11 is creating charge specific channels in the paracellular space

Homology for human CLDN11 (Claudin-11)

• homolog to PMP22 (for CNS),putative