CLDN11 / Claudin-11 Protein

Claudin 11 Protein Datasheet

CLDN11 / Claudin-11 Protein Product Information

• Synonym: CLDN11
• Protein Construction: A DNA sequence encoding the human CLDN11 (O75508 )(Val23-Arg82) was expressed with the Fc region of mouse IgG1 at the N-terminus.
• Source: Human
• Expression Host: Human Cells

CLDN11 / Claudin-11 Protein QC Testing

• Purity: > 90 % as determined by SDS-PAGE
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Asp
• Molecular Mass: The recombinant human CLDN11/mFc comprises 296 amino acids and has a predicted molecular mass of 33.2 kDa. The apparent molecular mass of the monomer is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: CLDN11 / Claudin-11 protein

CLDN11 / Claudin-11 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CLDN11 / Claudin-11 Protein Description

Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. As a physical barrier, tight junction strands can prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-11 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. A dysfunction of CLDN11 gene may cause human blood-testis barrier disruption. CLDN11 plays an important role in regulating proliferation and migration of oligodendrocytes.

References

1. Tsukita S. et al., 2001, Nat Rev Mol Cell Biol. 2 (4): 285-3.
2. Heiskala M. et al., 2001, Traffic. 2 (2): 93-8.
3. Bronstein JM. et al., 2000, J Neurosci Res. 59 (6): 706-11.