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Claudin 11 Protein Datasheet
CLDN11 / Claudin-11 Protein Price Inquiry ( Available Sizes )
CLDN11 / Claudin-11 Protein Product Information
A DNA sequence encoding the human CLDN11 (O75508 )(Val23-Arg82) was expressed with the Fc region of mouse IgG1 at the N-terminus.
|Expression Host:||Human Cells|
CLDN11 / Claudin-11 Protein QC Testing
|Purity:||> 90 % as determined by SDS-PAGE||SDS-PAGE:
CLDN11 / Claudin-11 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Asp|
The recombinant human CLDN11/mFc comprises 296 amino acids and has a predicted molecular mass of 33.2 kDa. The apparent molecular mass of the monomer is approximately 37 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
CLDN11 / Claudin-11 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CLDN11 / Claudin-11 Protein Related Products & Topics
CLDN11 / Claudin-11 Protein Description
Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. As a physical barrier, tight junction strands can prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-11 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. A dysfunction of CLDN11 gene may cause human blood-testis barrier disruption. CLDN11 plays an important role in regulating proliferation and migration of oligodendrocytes.
- Tsukita S. et al., 2001, Nat Rev Mol Cell Biol. 2 (4): 285-3.
- Heiskala M. et al., 2001, Traffic. 2 (2): 93-8.
- Bronstein JM. et al., 2000, J Neurosci Res. 59 (6): 706-11.