CIB2

The Calmyrin2 (CaMy2, Cib2) is a novel calcium-binding protein with EF-hand found recently in skeletal muscle. Calcium signals are transmitted by Ca2+ binding proteins, which own the same myristoylated N-terminus. CaMy2 is myristoylated in vivo, similarly as CaMy1 and VILIP1, which in response to Ca-signal exhibit redistribution from the cytoplasm to membranes by so called Ca/myristoyl switch. CaMy2 was detected mainly in subcellular membranes and no Ca-dependent translocation was observed. In summary, although CaMy2 and CaMy1 undergo myristoylation in vivo, they do not exhibit Ca/myristoyl switch, but instead seem constitutively associated with subcellular membranes. In addition, observed differences in subcellular localisation of the two members of CaMy protein family suggest they are specialized to transmit Ca transients at their specific membrane locations mediating different Ca-signaling pathways.

CIB2 Related Areas

Signal Transduction>>Calcium Signaling>>Calcium Binding Protein>>CIB2

CIB2 Alternative Names

CIB2, KIP2, KIP 2 [Homo sapiens]

Cib2, , KIP 2, RP23-259G10.1, 2810434I23Rik, AI449053 [Mus musculus]

Summaries for CIB2

Entrez Gene summary for CIB2:

The amino acid sequence the protein encoded by this gene is similar to that of KIP/CIB, calcineurin B, and calmodulin. This suggests that the encoded protein may be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

OMIM - description for CIB2:

DNA-dependent protein kinases (DNA-PK) play a role in the repair of double-strand DNA breaks and in the process of V(D)J recombination during lymphoid development. By EST database searching for sequences homologous to the DNA-PK gene KIP/CIB (602293) and 5-prime RACE, Seki et al. (1999) isolated a full-length cDNA, which they designated KIP2, from a human fetal brain cDNA library. KIP2 encodes a deduced 187-amino acid protein with a predicted molecular mass of 22 kD. The KIP2 protein shares 46%, 39%, and 30% sequence identity with the calcium-binding proteins KIP/CIB (602293), calcineurin B (601302), and calmodulin (114803), respectively. Sequence analysis of KIP2 revealed 2 EF-hand motifs and a helix-loop-helix motif involved in coordinating the calcium ion, indicating that KIP2 may also bind calcium. RT-PCR analysis indicated that KIP2 is ubiquitously expressed in various human tissues.

Wikipedia summary for CIB2:

Human CIB2 Protein General Information

 

• Protein names: Submitted name: CIB2 protein
• Sequence length: 144 AA.
• Domain: Repeat
• Sequence similarities: Contains 3 EF-hand domains.
• Tissue specificity: Ubiquitous.

General information above from UniProt

Function for CIB2 Protein

UniProtKB:

Genatlas:

• EF hand domain proteins family
• CIB2 may be a Ca2+-binding regulatory protein that interacts with DNA-dependent protein kinase catalytic subunit (DNA-PKcs)
• CIB2 havs a role as a cytoplasmic effector of integrin alpha7Bbeta1D signaling in skeletal muscle
• CIB2 plays a role in Ca2+ signaling underlying NMDAR activation

Homology for human CIB2

• ortholog to murine Cib2
• ortholog to rattus Cib2
• homolog to kip/B
• homolog to calcineurin
• homolog to calmodulin