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>CIB2 Protein & Antibody
CIB2 Protein & Antibody
Calcium and integrin binding family member 2
CIB2 Protein, Recombinant
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|CIB2||Human||CIB2 Protein, Recombinant||12596-H07E|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|Human CIB2||WB, ELISA||CIB2 Antibody||12596-RP01|
|Human CIB2||WB, ELISA||CIB2 Antibody (Antigen Affinity Purified)||12596-RP02|
|Human CIB2||ELISA||CIB2 Antibody||12596-R001|
CIB2 Related Areas
CIB2 Alternative Names
CIB2, KIP2, KIP 2 [Homo sapiens]
Cib2, , KIP 2, RP23-259G10.1, 2810434I23Rik, AI449053 [Mus musculus]
The Calmyrin2 (CaMy2, Cib2) is a novel calcium-binding protein with EF-hand found recently in skeletal muscle. Calcium signals are transmitted by Ca2+ binding proteins, which own the same myristoylated N-terminus. CaMy2 is myristoylated in vivo, similarly as CaMy1 and VILIP1, which in response to Ca-signal exhibit redistribution from the cytoplasm to membranes by so called Ca/myristoyl switch. CaMy2 was detected mainly in subcellular membranes and no Ca-dependent translocation was observed. In summary, although CaMy2 and CaMy1 undergo myristoylation in vivo, they do not exhibit Ca/myristoyl switch, but instead seem constitutively associated with subcellular membranes. In addition, observed differences in subcellular localisation of the two members of CaMy protein family suggest they are specialized to transmit Ca transients at their specific membrane locations mediating different Ca-signaling pathways.
CIB2 Related Studies
- Blazejczyk M, et al. (2006) Myristoylation and membranous localization of Calmyrin2, a new member of Neuronal Calcium-Sensor proteins. FENS Forum Abstracts. 3.
- Hollenbach AD, et al. (2006) The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1574(3): 321-8.
- Blazejczyk M, et al. (2009) Biochemical characterization and expression analysis of a novel EF-hand Ca2+ binding protein calmyrin2 (Cib2) in brain indicates its function in NMDA receptor mediated Ca2+ signaling. Archives of Biochemistry and Biophysics. 487(1): 66-78.