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CHODL Protein, Antibody, ELISA Kit, cDNA Clone

CHODL Related Areas

CHODL Related Pathways

CHODL Related Product

    CHODL Summary & Protein Information

    CHODL Background

    Gene Summary: This CHODL gene encodes a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. Chondrolectin localizes predominantly to the perinuclear region. Several transcript variants encoding a few different isoforms have been found for this CHODL gene.
    General information above from NCBI
    Subunit structure: Homodimer. Interacts with proteins of the S100 family S100A1, S100A6, S100B, S100P and S100A12 in a calcium-dependent manner (By similarity). Component of some large E3 complex at least composed of UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts directly with SIAH1, SIAH2 and SKP1.
    Subcellular location: Cytoplasm. Membrane; Single-pass type I membrane protein (Potential).
    Tissue specificity: Found in spleen, testis, prostate and fetal liver. Expression limited to vascular muscle of testis, smooth muscle of prostate stroma, heart muscle, skeletal muscle, crypts of small intestine, and red pulp of spleen.
    Post-translational: N-glycosylated.
    Sequence similarity: Contains 1 C-type lectin domain.
    General information above from UniProt

    CHODL Alternative Name

    C21orf68,CHODL,Chondrolectin,FLJ12627,MT75,PRED12, [human]
    3110074E07Rik,Chodl,Chondrolectin,MT75,PRED12, [mouse]

    CHODL Related Studies

  • Weng L, et al. (2003) A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. J Biol Chem. 278(21): 19164-70.
  • Masuda K, et al. (2011) Chondrolectin is a novel diagnostic biomarker and a therapeutic target for lung cancer. Clin Cancer Res. 17(24): 7712-22.
  • Weng L, et al. (2002) Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. Genomics. 80(1): 62-70.
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