CHL-1 Protein & Antibody

Cell adhesion molecule with homology to L1CAM

CHL-1 Products

CHL-1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CHL-1	Human	CHL-1 Protein, Recombinant	10143-H08H

  10143-H08H: When  5 x 10⁴ cells/well  are added to CHL1 coated plates (0.8 µg/mL and 100 µL/well), approximately 40%-60% will adhere specifically after 60 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells.

CHL-1 Antibody

Molecule	Application	Description	Cat. No
Human CHL-1	WB, ELISA	CHL-1 Antibody, Rabbit PAb	10143-RP01
Human CHL-1	WB, ELISA	CHL-1 Antibody, Rabbit PAb (Antigen Affinity Purified)	10143-RP02

CHL-1 cDNA Clone

Molecule	Species	Description	Cat. No
CHL-1	Human	Homo sapiens CHL-1 cDNA Clone	HG10143-C

CHL-1 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CHL-1

CHL-1 Alternative Names

CHL-1, CALL, L1CAM2, FLJ44930, MGC132578 [Homo sapiens]

CHL-1, Chl1, CALL, LICAM2, A530023M13Rik, AI465420 [Mus musculus]

CHL-1 Background

Neural cell adhesion molecule L1-like protein, also known as close homolog of L1 (CHL1) is the prototypic member of the CTF / NF-1 family of transcription factors that serve as a novel calcium signaling pathway-responsive transcription factor and is considered as a member of the largest ctf complementation group, consisting of 30 of 126 ctf mutants isolated. CHL1 is a cell adhesion molecule highly related to L1. It contains structure plan of six extracellular C2-type immunoglobulin (Ig) domains followed by five fibronectin typeⅢ domains linked by a single membrane-spanning region to a short cytoplasmic domain. The extracellular portion of CHL1 is higyly glycosylated and involved them in hemophilic disease.

CHL-1 Related Studies

1. Alevizopoulos A, et al. (1997) Regulation of the Transforming Growth Factor β-responsive Transcription Factor CTF-1 by Calcineurin and Calcium/ Calmodulin-dependent Protein Kinase IV. The Journal of Biological Chemistry. 272: 23597-605.
2. Gerring SL, et al.  (1990) The CHL1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2 / M. EMBO J. 9 (13): 4347–58.
3. Wei MH, et al. (1998) In silico-initiated cloning and molecular characterization of a novel human member of the L1 gene family of neural cell adhesion molecules. Human Genetics. 103 (3): 355-64.