CHK2 / CHEK2 Protein & Antibody

CHK2 checkpoint homolog (S. pombe)

CHK2 / CHEK2 Products

CHK2 / CHEK2 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CHK2/CHEK2	Mouse	CHK2/CHEK2 Protein, Recombinant, with GST Tag	50432-M20B

CHK2 / CHEK2 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse CHK2/CHEK2	IHC-P	CHK2 / CHEK2 Antibody (Antigen Affinity Purified)	50432-RP02

CHK2 / CHEK2 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CHK2/CHEK2	Human	Human CHK2/CHEK2 cDNA Clone / ORF Clone	HG11414-M
CHK2/CHEK2	Mouse	Mouse CHK2/CHEK2 cDNA Clone / ORF Clone	MG50432-M

CHK2 / CHEK2 Related Areas

Cancer>>Cell Cycle>>CHK2/CHEK2

CHK2 / CHEK2 Alternative Names

CHK2, CHEK2, RP11-436C9.1, CDS1, HuCds1, LFS2, PP1425, RAD53 [Homo sapiens]

CHK2, Chek2, CHK2, Cds1, HUCDS1, Rad53 [Mus musculus]

CHK2 / CHEK2 Background

Cell-cycle checkpoint kinase 2 (CHEK2), one of the protein kinase family and a mammalian homologue of the Saccharomyces cerevisiae Rad53 and Schizosaccharomyces pombe Cds1, is a central regulator in cell cycle progression and is a putative tumor regulator. The CHEK2 contains a forkhead-associated protein interaction region for activation in response to the DNA damage and replication blocks through rapidly phosphorylated in an ATM-dependent fashion. The phosphorylated CHEK2 kinase can phosphorylate several substrates, including Cdc25A, p53 and E2F1, which mediate cell cycle arrest and apoptosis. When activated, CHEK2 is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage.

CHK2 / CHEK2 Related Studies

1. Bogdanova N, et al. (2005) Association of two mutations in the CHEK2 gene with breast cancer. Cancer Genetics. 116(2) : 263-6.
2. Dong XY, et al. (2003) Mutations in CHEK2 associated with prostate cancer risk. The American journal of human genetics. 72(2) 270-80.