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CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified

  • CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
  • CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
  • CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Mouse CHK2/CHEK2 Antibody Product Information
Immunogen:Recombinant Mouse CHK2 / CHEK2 protein (Catalog#50432-M20B)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:Produced in rabbits immunized with purified, recombinant Mouse CHK2 / CHEK2 (rM CHK2 / CHEK2; Catalog#50432-M20B; Q9Z265; Mey1-Leu 546). CHK2 / CHEK2 specific IgG was purified by Mouse CHK2 / CHEK2 affinity chromatography.
Mouse CHK2/CHEK2 Antibody WB Application Image
Mouse CHK2/CHEK2 Antibody IHC Application Image
CHK2 / CHEK2 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CHEK2 in mouse spleen with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Mouse CHK2/CHEK2 Antibody IP Application Image
Other CHK2/CHEK2 Antibody Products
CHK2/CHEK2 Background

In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by CHEK2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded CHEK2 protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in CHEK2s gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Mouse CHK2/CHEK2 References
  • Bogdanova N, et al. (2005) Association of two mutations in the CHEK2 gene with breast cancer. Cancer Genetics. 116(2) : 263-6.
  • Dong XY, et al. (2003) Mutations in CHEK2 associated with prostate cancer risk. The American journal of human genetics. 72(2) 270-80.
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    Catalog: 50432-RP02-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"