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CHI3L1/YKL40 Protein, Antibody, ELISA Kit, cDNA Clone

CHI3L1/YKL40 Related Areas

CHI3L1/YKL40 Related Pathways

CHI3L1/YKL40 Related Product

    CHI3L1/YKL40 Summary & Protein Information

    CHI3L1/YKL40 Background

    Gene Summary: Chitinases catalyze the hydrolysis of chitin, which is an abundant glycopolymer found in insect exoskeletons and fungal cell walls. The glycoside hydrolase 18 family of chitinases includes eight human family members. This CHI3L1 gene encodes a glycoprotein member of the glycosyl hydrolase 18 family. CHI3L1 protein lacks chitinase activity and is secreted by activated macrophages, chondrocytes, neutrophils and synovial cells. CHI3L1 is thought to play a role in the process of inflammation and tissue remodeling. [provided by RefSeq, Sep 2009]
    General information above from NCBI
    Subunit structure: Monomer.
    Subcellular location: Secreted, extracellular space.
    Tissue specificity: Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts.
    Post-translational: Glycosylated.
    Involvement in disease: Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma- related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Sequence similarity: Belongs to the glycosyl hydrolase 18 family.
    General information above from UniProt

    Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

    CHI3L1/YKL40 Alternative Name

    HCGP-3P,YKL40,YYL-40,gp39,ASRT7,CHI3L1,DKFZp686N19119,FLJ38139,HC-gp39, [human]
    gp39,AW208766,Brp39,CHI3L1, [mouse]

    CHI3L1/YKL40 Related Studies

  • Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3-Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.
  • Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67.
  • Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87
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