All CHI3L1 reagents are produced in house and quality controlled, including 5 CHI3L1 Antibody, 24 CHI3L1 Gene, 2 CHI3L1 Lysate, 2 CHI3L1 Protein, 2 CHI3L1 qPCR. All CHI3L1 reagents are ready to use.
Recombinant CHI3L1 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CHI3L1antibodies are validated with different applications, which are ELISA, IHC-P, WB.
CHI3L1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CHI3L1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.