CHI3L1 Protein & Antibody (YKL40 Protein)

Chitinase 3-Like 1 (Cartilage Glycoprotein-39)

CHI3L1 Protein Products

CHI3L1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CHI3L1/YKL40	Human	CHI3L1/YKL40 Protein, Recombinant	11227-H08H
CHI3L1/YKL40	Mouse	CHI3L1 / gp39 Protein, Recombinant	50929-M08H

  11227-H08H:  When cells are added to recombinant human CHI3L1 coated plates (1.5 µg/mL, 100 µL/well) , approximately 65%-75% will adhere specifically after 30 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of Fadu human squamous cell carcinoma cells (ATCC:HTB43).

CHI3L1 Antibody

Molecule	Application	Description	Cat. No
Human CHI3L1/YKL40	WB, ELISA	CHI3L1 / YKL40 Antibody	11227-RP01
Human CHI3L1/YKL40	WB, ELISA	CHI3L1 / YKL40 Antibody (Antigen Affinity Purified)	11227-RP02

CHI3L1 cDNA Clone

Molecule	Species	Description	Cat. No
CHI3L1/YKL40	Human	Homo sapiens CHI3L1/YKL40 DNA ORF clone(NM_001276.2)	HG11227-M
CHI3L1/YKL40	Mouse	Mouse CHI3L1/YKL40 cDNA Clone / ORF Clone	MG50929-G

CHI3L1 Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>>CHI3L1

CHI3L1 Alternative Names

CHI3L1, YKL40, GP39, HC-gp39, ASRT7, DKFZp686N19119, FLJ38139, HCGP-3P, YYL-40 [Homo sapiens]

CHI3L1, Gp39, AW208766, Brp39 [Mus musculus]

CHI3L1 Background

Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

CHI3L1 Related Studies

1. Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3–Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.
2. Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67.
3. Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87