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CHI3L1 Protein & Antibody (YKL40 Protein)

Chitinase 3-Like 1 (Cartilage Glycoprotein-39)

CHI3L1 Protein Products

CHI3L1 Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CHI3L1/YKL40 Human CHI3L1/YKL40 Protein, Recombinant 11227-H08H
CHI3L1/YKL40 Mouse CHI3L1 / gp39 Protein, Recombinant 50929-M08H

  11227-H08H:  When cells are added to recombinant human CHI3L1 coated plates (1.5 µg/mL, 100 µL/well) , approximately 65%-75% will adhere specifically after 30 minutes at 37℃. Measured by the ability of the immobilized protein to support the adhesion of Fadu human squamous cell carcinoma cells (ATCC:HTB43).

CHI3L1 Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human CHI3L1/YKL40 WB, ELISA CHI3L1 / YKL40 Antibody 11227-RP01
Human CHI3L1/YKL40 WB, ELISA CHI3L1 / YKL40 Antibody (Antigen Affinity Purified) 11227-RP02
Human CHI3L1/YKL40 IHC-P CHI3L1 / YKL40 Antibody 11227-MM04

CHI3L1 cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
CHI3L1/YKL40 Human Homo sapiens CHI3L1/YKL40 DNA ORF clone(NM_001276.2) HG11227-M
CHI3L1/YKL40 Human Human CHI3L1 / YKL40 ORF Expression Clone, His-tagged HG11227-M-H
CHI3L1/YKL40 Mouse Mouse CHI3L1/YKL40 cDNA Clone / ORF Clone MG50929-G

CHI3L1 Related Areas

Enzyme>>Carbohydrate Metabolism Enzymes>>CHI3L1

CHI3L1 Alternative Names

CHI3L1, YKL40, GP39, HC-gp39, ASRT7, DKFZp686N19119, FLJ38139, HCGP-3P, YYL-40 [Homo sapiens]

CHI3L1, Gp39, AW208766, Brp39 [Mus musculus]

CHI3L1 Background

Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high levels in postconfluent nodular VSMC cultures and at low levels in subconfluent proliferating cultures. CHI3L1 is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18. In contrast to many other monocyto / macrophage markers, its expression is absent in monocytes and strong induced during late stages of human macrophage differentiation. Elevated levels of CHI3L1 are associated with disorders exhibiting increased connective tissue turnover, such as rheum atoid, arthritis, osteoarthritis, scleroderma, and cirrhosis of liver, but is produced in cartilage from old donors or patiens with osteoarthritis. CHI3L1 is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia.

CHI3L1 Related Studies

  1. Zhao XZH, et al. (2007) Functional Variants in the Promoter Region of Chitinase 3–Like 1 (CHI3L1) and Susceptibility to Schizophrenia.The American Journal of Human Genetics. 80 (1): 12-18.
  2. Rehli M, et al. (2003) Transcriptional Regulation of CHI3L1, a Marker Gene for Late Stages of Macrophage Differentiation . The Journal of Biological Chemistry. 278: 44058-67.
  3. Nishikawa KC, et al. (2003) gp38k (CHI3L1) is a novel adhesion and migration factor for vascular cells. Experimental Cell Research. 287 (1): 79-87

 

 

CHI3L1 (YKL40) related areas, pathways, and other information

 

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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