All Cofilin reagents are produced in house and quality controlled, including 1 Cofilin Antibody, 62 Cofilin Gene, 1 Cofilin IPKit, 1 Cofilin Protein, 2 Cofilin qPCR. All Cofilin reagents are ready to use.
Recombinant Cofilin proteins are expressed by E. coli with fusion tags as N-His.
Cofilinantibodies are validated with different applications, which are WB, ELISA, IHC-P, IP.
CofilincDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Cofilin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CFL1, also known as n-cofilin, is a member of the ADF/Cofilin family. This family comprises three genes: CFL1, CFL2 and DSTN (destrin). ADF/Cofilin family members bind G-actin monomers and depolymerize actin filaments through two mechanisms: severing and increasing the off-rate for actin monomers from the pointed end. Cofilin also binds with other proteins such as myosin, tropomyosin, α-actinin, gelsolin and scruin. These proteins compete with cofilin for actin binding. Сofilin also plays a role in innate immune response. CFL1 contains 1 ADF-H domain and is widely distributed in various tissues. It is important for normal progress through mitosis and normal cytokinesis.