This CFHR1 gene encodes a secreted protein belonging to the complement factor H protein family. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this CFHR1 gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
OMIM-Description for CFHR1
Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene.