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CFHR1  Protein, Antibody, ELISA Kit, cDNA Clone

CFHR1 Related Area

CFHR1 Related Pathways

    CFHR1 Related Protein, Antibody, cDNA Gene, and ELISA Kits

    CFHR1 Summary & Protein Information

    CFHR1 Background

    Gene Summary: This CFHR1 gene encodes a secreted protein belonging to the complement factor H protein family. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this CFHR1 gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
    General information above from NCBI
    Subunit structure: Head-to-tail homodimer and heterodimer with CFHR2 or CFHR5. {ECO:0000269|PubMed:23487775}.
    Subcellular location: Secreted.
    Tissue specificity: Expressed by the liver and secreted in plasma.
    Post-translational: N-glycosylated. Two forms are observed; one with a single side chain and the other with two. {ECO:0000269|PubMed:16335952}.
    Sequence similarity: Contains 5 Sushi (CCP/SCR) domains. {ECO:0000255|PROSITE-ProRule:PRU00302}.
    General information above from UniProt

    CFHR1 is a secreted protein belonging to the complement factor H protein family.The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR1 binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. CFHR1 might be involved in complement regulation. It can associate with lipoproteins and may play a role in lipid metabolism.

    CFHR1 Alternative Name

    CFHL,CFHL1,CFHL1P,CFHR1P,complement factor H-related 1 pseudogene,complement factor H-related protein 1,FHR1,FHR-1,H factor (complement)-like 1,H factor (complement)-like 2,h factor-like protein 1,H36,H36-1,H36-2,H-factor-like 1,HFL1,HFL2, [human]
    AI194696,Cfhl1,CFHRB,complement component factor h-like 1,complement factor H-related protein, [mouse]

    CFHR1 Related Studies

  • Martnez-Barrica, et al. (2012) Relevance of complement factor H-related 1 (CFHR1) genotypes in age-related macular degeneration. Invest Ophthalmol Vis Sci. 53(3):1087-94.
  • Leban N, et al. (2012) Factor H and CFHR1 polymorphisms associated with atypical Haemolytic Uraemic Syndrome (aHUS) are differently expressed in Tunisian and in Caucasian populations. Int J Immunogenet. 39(2):110-3.
  • Kubista KE, et al. (2011) Copy number variation in the complement factor H-related genes and age-related macular degeneration. Int J Immunogenet. Mol Vis. 17:2080-92.
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