Anti-CES3 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human CES3 / Carboxylesterase 3 protein (Catalog#11129-H08H)
Produced in rabbits immunized with purified, recombinant Human CES3 / Carboxylesterase 3 (rh CES3 / Carboxylesterase 3; Catalog#11129-H08H; NP_079198.2; Met 1-Glu 561). CES3 / Carboxylesterase 3 specific IgG was purified by Human CES3 / Carboxylesterase 3 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CES3 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CES3 Antibody Alternative Names
Anti-ES31 Antibody;Anti-FLJ21736 Antibody;Anti-UNQ869/PRO1887 Antibody
CES3 Background Information
Carboxylesterases hydrolyze esters of short-chain fatty acids and have roles in animals ranging from signal transduction to xenobiotic detoxification. In enzymology, a carboxylesterase is an enzyme that catalyzes the chemical reaction: a carboxylic ester + H2O = an alcohol + a carboxylate. Most enzymes from this group belong to the superfamily of hydrolases with alpha/beta protein fold (so called Alpha/beta hydrolase fold), specifically those acting on carboxylic ester bonds. The carboxylesterase family of evolutionarily related proteins (those with clear sequence homology to each other) includes a number of proteins with different substrate specificities, such as acetylcholinesterases. Carboxylesterase 3, also known as Liver carboxylesterase 31 homolog and CES3, is a endoplasmic reticulum lumen which belongs to the type-B carboxylesterase/lipase family. CES3 is involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. CES3 shows low catalytic efficiency for hydrolysis of CPT-11, a prodrug for camptothecin used in cancer therapeutics. CES3 is expressed in liver, colon and small intestine.
Augusteyn RC. et al.,1969, Biochim Biophys Acta. 171 (1): 128-37. Saito S. et al., 2003, J. Hum. Genet. 48: 249-70. Sanghani SP. et al., 2003, Clin Cancer Res. 9: 4983-91. Sanghani SP. et al., 2004, Drug Metab Dispos. 32: 505-11. Chen R. et al., 2009, J Proteome Res. 8: 651-61.