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CES2 / Carboxylesterase 2 Antibody, Rabbit PAb, Antigen Affinity Purified

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    Human CES2 Antibody Product Information
    Immunogen:Recombinant Human CES2 / Carboxylesterase 2 protein (Catalog#10380-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human CES2 / Carboxylesterase 2 (rh CES2 / Carboxylesterase 2; Catalog#10380-H08H; O00748-1; Met 1-Leu 559). CES2 / Carboxylesterase 2 specific IgG was purified by Human CES2 / Carboxylesterase 2 affinity chromatography.
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    CES2/Carboxylesterase 2 Background

    Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

    Human CES2/Carboxylesterase 2 References
  • Imai T. et al. (2006) Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug metab pharmacokinet. 21 (3): 173-85.
  • Guang Xu, et al. (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res. 8: 2605.
  • Zhang, et al. (2002) Comprehensive Evaluation of Carboxylesterase-2 Expression in Normal Human Tissues Using Tissue Array Analysis. Applied Immunohistochemistry & Molecular Morphology. 10 (4): 374-80.
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