Anti-CES2 Antibody

Cat: 50515-RP01
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Anti-CES2 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CES2 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Mouse
Specificity
Mouse CES2
Immunogen
Recombinant Mouse CES2 / Carboxylesterase 2 protein (Catalog#50515-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CES2 / Carboxylesterase 2 (rM CES2 / Carboxylesterase 2; Catalog#50515-M08H; NP_663578.1; Met 1-Lys 557). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CES2 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CES2 Antibody Alternative Names
Anti-ces2A3 Antibody
CES2 Background Information

Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.

Full Name
carboxylesterase 2
References
  • Imai T. et al. (2006) Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug metab pharmacokinet. 21 (3): 173-85.
  • Guang Xu, et al. (2002) Human carboxylesterase 2 is commonly expressed in tumor tissue and is correlated with activation of irinotecan. Clin Cancer Res. 8: 2605.
  • Zhang, et al. (2002) Comprehensive Evaluation of Carboxylesterase-2 Expression in Normal Human Tissues Using Tissue Array Analysis. Applied Immunohistochemistry & Molecular Morphology. 10 (4): 374-80.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CES2 Antibody Rabbit Polyclonal ELISA,IHC-P 50515-RP02
    Anti-CES2 Antibody Rabbit Polyclonal ELISA 10380-RP01
    Anti-CES2 Antibody Rabbit Polyclonal ELISA 10380-RP02
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