CEACAM8 Protein & Antibody (CD66b)

Carcinoembryonic antigen (CEA)-related Cell Adhesion Molecule 8 (Cluster of Differentiation 66b)

CEACAM8 Products

CEACAM8 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CEACAM8 /CD66b	Human	CEACAM8/CD66b Protein, Recombinant	11729-H08H

CEACAM8 Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CEACAM8 /CD66b	WB, ELISA	CEACAM8/CD66b Antibody, Rabbit PAb	11729-RP01
Human CEACAM8 /CD66b	WB, ELISA	CEACAM8/CD66b Antibody, Rabbit PAb (Antigen Affinity Purified)	11729-RP02
Human CEACAM8 /CD66b	WB, ELISA	CEACAM8 / CD66b Antibody	11729-MM04

CEACAM8 cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CEACAM8 /CD66b	Human	Homo sapiens CEACAM8/CD66b cDNA Clone	HG11729-G

CEACAM8 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CEACAM8/CD66b

Immunology>>Cluster of Differentiation>>CEACAM8/CD66b

CEACAM8 Alternative Names

CEACAM8, CD66b, CD67, CGM6, NCA-95 [Homo sapiens]

CEACAM8 Background

CEACAM8, also known as CD66b or NCA-95, is a single chain, GPI-anchored, highly glycosylated protein belonging to the carcinoembryonic antigen family. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM8(CD66b) is also an activation marker for human granulocytes. However, its biological functions are largely unknown in eosinophils. It has been reported that CD66b is highly expressed on the surface of human peripheral blood eosinophils isolated from healthy individuals. Engagement of CD66b by mAb or a natural ligand, galectin-3, activated a Src kinase family molecule, hemopoietic cell kinase (Hck), and induced cellular adhesion, superoxide production, and degranulation of eosinophils. CD66b molecules were localized in lipid rafts, and disruption of lipid rafts or removal of the GPI anchor inhibited the adhesion and activation of eosinophils. Importantly, CD66b was constitutively and physically associated with a beta2 integrin, CD11b, and cross-linking of CD66b induced a striking clustering of CD11b molecules. Thus, CD66b molecules are involved in regulating adhesion and activation of eosinophils, possibly through their localization in lipid rafts and interaction with other cell surface molecules, such as CD11b. Binding of exogenous or endogenous carbohydrate ligands(s) to CD66b may be important in the release of proinflammatory mediators by human eosinophils.

CEACAM8 Related Studies

1. Yoon J, et al. (2007) CD66b regulates adhesion and activation of human eosinophils. J Immunol. 179 (12): 8454-62.
2. Skubitz KM, et al. (1996) CD6a, CD66b, CD66c, and CD66d each independently stimulate neutrophils. J Leukoc Biol. 60 (1): 106-17.
3. Skubitz KM, et al. (2008) Inte rdependency of CEACAM-1, -3, -6, and -8 induced human neutrophil adhesion to endothelial cells. J Transl Med. 6: 78.
4. Lasa A, et al. (2008) High expression of CEACAM6 and CEACAM8 mRNA in acute lymphoblastic leukemias. Ann Hematol. 87 (3): 205-11.