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CEACAM6 / CD66c Antibody, Rabbit MAb

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Human CEACAM6 Antibody Product Information
Immunogen:Recombinant Human CD66c protein (Catalog#10823-H08H)
Clone ID:408
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM6 (rhCEACAM6; Catalog#10823-H08H; NP_002474.3; Met 1-Gly 320).
Human CEACAM6 Antibody Usage Guide
Specificity:Human CEACAM6 / CD66c
No cross-reactivity in ELISA with
Human CEACAM1 / CD66a
Human CEACAM5 / CD66e
Application:ELISA, FCM

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human CEACAM6. The detection limit for Human CEACAM6 is approximately 0.00245 ng/well.

FCM: 0.5-2 μg/Test

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human CEACAM6 Antibody FC Application Image
CEACAM6 / CD66c Antibody, Rabbit MAb, Flow cytometric analysis
[Click to enlarge image]
Flow cytometric analysis of Human CEACAM6 expression on human peripheral blood granulocytes. Cells were stained with purified anti-Human CEACAM6, then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of viable granulocytes.
Other CEACAM6 Antibody Products
CEACAM6/CD66c Background

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.

Human CEACAM6/CD66c References
  • Duxbury MS, et al. (2004) Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 23(34): 5834-42.
  • Lewis-Wambi JS, et al. (2008) Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44(12): 1770-9.
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    Size / Price
    Catalog: 10823-R408-50
    List Price: 
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    50 µg
    100 µg
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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.