Anti-CEACAM6 Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-CEACAM6 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CEACAM6
Immunogen
Recombinant Human CEACAM6 / CD66c Protein (Catalog#10823-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human CEACAM6 (rh CEACAM6; Catalog#10823-H08H; NP_002474.3; Met 1-Gly 320).
Source
Monoclonal Rabbit IgG Clone #02
Formulation
PBS, 5% Trehalose
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CEACAM6 Antibody (Rabbit Monoclonal antibody) Validated Applications
| Application |
Dilution |
Notes |
| ELISA |
1:5000-1:10000 |
|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CEACAM6 Antibody Alternative Names
Anti-CD66c Antibody;Anti-CEA Antibody;Anti-CEAL Antibody;Anti-NCA Antibody
CEACAM6 Background Information
Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6), also known as nonspecific crossreacting antigen (NCA) and CD66c, is one of seven human CEACAM family members within the immunoglobulin superfamily. It s a glycosylphosphatidylinositol-linked immunoglobulin superfamily member that is overexpressed in a variety of human cancers, including colon, breast and lung and is associated with tumourigenesis, tumour cell adhesion, invasion and metastasis. CEACAM6 is a unique mediator of migration and invasion of drug resistant oestrogen-deprived breast cancer cells, and this protein could be an important biomarker of metastasis. CEACAM6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
Full Name
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
References
Duxbury MS, et al. (2004) Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 23(34): 5834-42.Lewis-Wambi JS, et al. (2008) Overexpression of CEACAM6 promotes migration and invasion of oestrogen-deprived breast cancer cells. Eur J Cancer. 44(12): 1770-9.
