CEACAM5 Protein & Antibody (CD66e)

Carcinoembryonic antigen (CEA)-related Cell Adhesion Molecule 5 (Cluster of Differentiation 66e)

CEACAM5 Protein Products

CEACAM5 Protein, Recombinant

Molecule	Species	Description	Cat. No
CEACAM5/CD66e	Human	CEACAM5/CD66e/Fc Protein, Recombinant	11077-H03H
CEACAM5/CD66e	Human	CEACAM5/CD66e Protein, Recombinant	11077-H08H

CEACAM5 Antibody

Molecule	Application	Description	Cat. No
Human CEACAM5/CD66e	WB, ELISA	CEACAM5/CD66e Antibody, Rabbit PAb	11077-RP01
Human CEACAM5/CD66e	WB, ELISA	CEACAM5/CD66e Antibody, Rabbit PAb (Antigen Affinity Purified)	11077-RP02
Human CEACAM5/CD66e	WB	CEACAM5/CD66e Antibody, Mouse MAb	11077-MM05
Human CEACAM5/CD66e	ELISA	CEACAM5/CD66e Antibody, Mouse MAb	11077-MM07
Human CEACAM5/CD66e	ELISA, IHC-P	CEACAM5 / CD66e Antibody	11077-MM08

CEACAM5 ELISA Kits

Molecule	Application	Description	Cat. No
Human CEACAM5/CD66e	ELISA	CEACAM5 / CD66e ELISA Pair Set, Human ELISA Pair Set	SEK11077

CEACAM5 cDNA Clone

Molecule	Species	Description	Cat. No
CEACAM5/CD66e	Human	Homo sapiens CEACAM5/CD66e cDNA Clone(NM_004363.2)	HG11077-M

CEACAM5 Related Areas

Cancer>>Cancer Biomarkers>>CEACAM5/CD66e

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>CEACAM5/CD66e

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CEACAM5/CD66e

CEACAM5 Alternative Names

CEACAM5, CD66e, CEA, DKFZp781M2392 [Homo sapiens]

CEACAM5 Background

CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

CEACAM5 Related Studies

1. Baczyńska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
2. Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
3. Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.