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CEACAM5 / CD66e Antibody, Rabbit PAb

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    Human CEACAM5 Antibody Product Information
    Immunogen:Recombinant Human CD66e protein (Catalog#11077-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant Human CEACAM5 (rh CEACAM5; Catalog#11077-H08H; NP_004354.2; Met 1-Ala 685). Total IgG was purified by Protein A affinity chromatography.
    Other CEACAM5 Antibody Products
    Reactivity: Human  
    Application: ELISA  
      11077-R076-50
      11077-R076-100
      50 µg 
      100 µg 
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      Reactivity: Human  
      Application: FCM  
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      11077-R061-P-25
      11077-R061-P-100
      25 Test 
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      Reactivity: Human  
      Application: 
        11077-MM04-50
        11077-MM04-200
        11077-MM04-100
        11077-MM04-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
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        11077-R061-F-25
        11077-R061-F-100
        25 Test 
        100 Tests 
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        Reactivity: Human  
        Application: FCM  
        • Slide 1
        11077-R061-50
        11077-R061-100
        50 µg 
        100 µg 
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        Reactivity: Human  
        Application: ELISA  
          11077-R017-50
          11077-R017-100
          50 µg 
          100 µg 
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          Reactivity: Human  
          Application: ELISA  
            11077-MM07-50
            11077-MM07-200
            11077-MM07-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactivity: Human  
            Application: FCM  
            • Slide 1
            11077-MM02-P-25
            11077-MM02-P-100
            25 Test 
            100 Tests 
            Add to Cart
            Reactivity: Human  
            Application: 
              11077-MM02-50
              11077-MM02-200
              11077-MM02-100
              11077-MM02-1
              50 µg 
              200 µg 
              100 µg 
              1 mg 
              Add to Cart
              Reactivity: Human  
              Application: ELISA  
                11077-R005-50
                11077-R005-100
                50 µg 
                100 µg 
                Add to Cart
                Reactivity: Human  
                Application: ELISA  IHC-P  
                • Slide 1
                11077-MM08-50
                11077-MM08-200
                11077-MM08-100
                50 µg 
                200 µg 
                100 µg 
                Add to Cart
                Reactivity: Human  
                Application: FCM  
                • Slide 1
                11077-R061-A-25
                11077-R061-A-100
                25 Test 
                100 Tests 
                Add to Cart
                Reactivity: Human  
                Application: ELISA  
                  11077-RP02-50
                  11077-RP02-200
                  11077-RP02-100
                  50 µg 
                  200 µg 
                  100 µg 
                  Add to Cart
                  Reactivity: Human  
                  Application: IHC-P  
                  • Slide 1
                  • Slide 1
                  11077-R327-50
                  11077-R327-100
                  50 µg 
                  100 µg 
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                  CEACAM5/CEA/CD66e Background

                  CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

                  Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

                  Human CEACAM5/CEA/CD66e References
                • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
                • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
                • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.
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                  Catalog: 11077-RP01-400
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                  Datasheet & Documentation

                  All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                  Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"