Anti-CEACAM5 Antibody (PE)

Cat: 11077-MM02-P
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Anti-CEACAM5 Antibody (PE) (Mouse Monoclonal antibody) General Information
Product name
Anti-CEACAM5 Antibody (PE)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human CEACAM5
Immunogen
Recombinant Human CEACAM5 / CD66e protein (Catalog#11077-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; Catalog#11077-H08H; NP_004354.2; Met1-Ala685) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Source
Monoclonal Mouse IgG2a Clone #02
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
PE
Concentration
2 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-CEACAM5 Antibody (PE) (Mouse Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CEACAM5 Antibody (PE) (Mouse Monoclonal antibody) Images
Human CEACAM5/CEA/CD66e Flow Cytometry (FC) 5405
Flow cytometric analysis of anti-Human CEACAM5 on HT29 cells.
Anti-CEACAM5 Antibody (PE) Alternative Names
Anti-CD66e Antibody;Anti-CEA Antibody
CEACAM5 Background Information

CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
carcinoembryonic antigen-related cell adhesion molecule 5
References
  • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
  • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
  • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CEACAM5 Antibody Rabbit Polyclonal ELISA 11077-RP01
    Anti-CEACAM5 Antibody Mouse Monoclonal ELISA(Cap) 11077-MM02
    Anti-CEACAM5 Antibody Mouse Monoclonal ELISA(Det) 11077-MM04
    Anti-CEACAM5 Antibody Rabbit Monoclonal IHC-P 11077-R327
    Anti-CEACAM5 Antibody Rabbit Monoclonal ELISA 11077-R076
    Anti-CEACAM5 Antibody Mouse Monoclonal ELISA,IHC-P 11077-MM08
    Anti-CEACAM5 Antibody (APC) Rabbit Monoclonal FCM 11077-R061-A
    Anti-CEACAM5 Antibody (PE) Rabbit Monoclonal FCM 11077-R061-P
    Anti-CEACAM5 Antibody Rabbit Polyclonal ELISA 11077-RP02
    Anti-CEACAM5 Antibody Mouse Monoclonal ELISA 11077-MM07
    Anti-CEACAM5 Antibody Rabbit Monoclonal ELISA 11077-R005
    Anti-CEACAM5 Antibody Rabbit Monoclonal ELISA 11077-R017
    Anti-CEACAM5 Antibody Rabbit Monoclonal FCM 11077-R061
    Anti-CEACAM5 Antibody (FITC) Rabbit Monoclonal FCM 11077-R061-F
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