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CEACAM5 / CD66e Antibody (PE), Mouse MAb

  • CEACAM5 / CD66e Antibody (PE), Mouse MAb, Flow cytometric
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Human CEACAM5 Antibody Product Information
Immunogen:Recombinant Human CEACAM5 / CD66e protein (Catalog#11077-H08H)
Clone ID:02
Ig Type:Mouse IgG2a
Concentration:2 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM5 / CD66e (rh CEACAM5 / CD66e; Catalog#11077-H08H; NP_004354.2; Met1-Ala685) and conjugated with PE under optimum conditions, the unreacted PE was removed.
Human CEACAM5 Antibody FC Application Image
CEACAM5 / CD66e Antibody (PE), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of anti-Human CEACAM5 on HT29 cells.
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            Reactivity: Human  
            Application: IHC-P  
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            CEACAM5/CEA/CD66e Background

            CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domain and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.

            Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

            Human CEACAM5/CEA/CD66e References
          • Baczyska D, et al. (2003) The tumorigenic potential of human CX-1 colon adenocarcinoma cells depends on carcinoembryonic antigen (CEACAM5) expression. Cell Mol Biol Lett. 8(2): 471-86.
          • Blumenthal RD, et al. (2005) Inhibition of adhesion, invasion, and metastasis by antibodies targeting CEACAM6 (NCA-90) and CEACAM5 (Carcinoembryonic Antigen). Cancer Res. 65(19): 8809-17.
          • Liebig B, et al. (2005) Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Cancer Lett. 223(1): 159-67.
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            Catalog: 11077-MM02-P-25
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            Datasheet & Documentation

            All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
            Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"