All CEACAM3 reagents are produced in house and quality controlled, including 6 CEACAM3 Antibody, 2 CEACAM3 Gene, 1 CEACAM3 Lysate, 1 CEACAM3 Protein, 1 CEACAM3 qPCR. All CEACAM3 reagents are ready to use.
Recombinant CEACAM3 proteins are expressed by HEK293 Cells with fusion tags as C-His.
CEACAM3antibodies are validated with different applications, which are ELISA, FCM, IHC-P.
CEACAM3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CEACAM3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.