CEACAM3 Protein & Antibody (CD66d Protein)

Carcinoembryonic antigen (CEA)-related Cell Adhesion Molecule 3 (Cluster of Differentiation 66d)

CEACAM3 Products

CEACAM3 Protein, Recombinant

Molecule	Species	Description	Cat. No
CEACAM3/CD66d	Human	CEACAM3/CD66d Protein, Recombinant	11933-H08H

CEACAM3 Antibody

Molecule	Application	Description	Cat. No
Human CEACAM3/CD66d	WB,ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11933-RP02
Human CEACAM3/CD66d	WB,ELISA	CEACAM3 / CD66d Antibody	11933-MM03

CEACAM3 Related Areas

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>CEACAM3/CD66d

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Neutrophils>>CEACAM3/CD66d

CEACAM3 Alternative Names

CEACAM3, CD66D, CEA, CGM1, MGC119875, W264, W282 [Homo sapiens]

Ceacam3, EG384557, Psg24, cea12 [Mus musculus]

CEACAM3 Background

CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.

CEACAM3 Related Studies

1. Schmitter T, et al. (2007) The Granulocyte Receptor Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) Directly Associates with Vav to Promote Phagocytosis of Human Pathogens. The journal of immunology. 178: 3797-805.
2. Swanson KV, et al. (2001) CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells. Cellular Microbiology. 3 (10): 681-91.
3. Hasselbalch HC, et al. (2011) High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis. Leukemia Research.