Anti-CEACAM3 Antibody

Cat: 11933-MM03
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Anti-CEACAM3 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-CEACAM3 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human CEACAM3
No cross-reactivity in ELISA with Human CEACAM1 Human CEACAM5 Human CEACAM6 Human cell lysate (293 cell line)
Immunogen
Recombinant Human CEACAM3 / CD66d protein (Catalog#11933-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CEACAM3 / CD66d (rh CEACAM3 / CD66d; Catalog#11933-H08H; NP_001806.2; Met 1-Gly 155). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #5D1A2
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CEACAM3 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CEACAM3 Antibody Alternative Names
Anti-CD66D Antibody;Anti-CEA Antibody;Anti-CGM1 Antibody;Anti-MGC119875 Antibody;Anti-W264 Antibody;Anti-W282 Antibody
CEACAM3 Background Information

CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66a, CD66b, CD66c, and CD66d. Members of CEACAM family are widely expressed especially on human neutrophils, and, depending on the tissue, capable of regulating diverse functions including tumor promotion, tumor suppression, angiogenesis, and neutrophil activation. Abnormal overexpression and downregulation of some CEACAMs have been described in tumor cells. Monoclonal antibodies grouped in the CD66 cluster recognize CEACAM members. Ectopic CD66 expression is commonly detected in B-cell lineage acute lymphoblastic leukemia (ALL). CEACAM3 mediates phagocytosis depends on the integrity of an ITAM-like sequence within the cytoplasmic domain of CEACAM3. CEACAM3 is characterized by rapid stimulation of the GTPase Rac.

Full Name
carcinoembryonic antigen related cell adhesion molecule 3
References
  • Schmitter T, et al. (2007) The Granulocyte Receptor Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 (CEACAM3) Directly Associates with Vav to Promote Phagocytosis of Human Pathogens. The journal of immunology. 178: 3797-805.
  • Swanson KV, et al. (2001) CEACAM is not necessary for Neisseria gonorrhoeae to adhere to and invade female genital epithelial cells. Cellular Microbiology. 3 (10): 681-91.
  • Hasselbalch HC, et al. (2011) High expression of carcinoembryonic antigen-related cell adhesion molecule (CEACAM) 6 and 8 in primary myelofibrosis. Leukemia Research.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CEACAM3 Antibody (PE) Mouse Monoclonal FCM 11933-MM06-P
    Anti-CEACAM3 Antibody Rabbit Polyclonal ELISA 11933-RP01
    Anti-CEACAM3 Antibody Rabbit Polyclonal ELISA 11933-RP02
    Anti-CEACAM3 Antibody Mouse Monoclonal FCM 11933-MM06
    Anti-CEACAM3 Antibody Rabbit Polyclonal ELISA,IHC-P 11933-T24
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