Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CEACAM1 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse CEACAM1
Immunogen
Recombinant Mouse CEACAM1 / CD66a protein (Catalog#50571-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse CEACAM1 / CD66a (rM CEACAM1 / CD66a; Catalog#50571-M08H; NP_001034274.1; Met 1-Gly 428). CEACAM1 / CD66a specific IgG was purified by Mouse CEACAM1 / CD66a affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) Validated Applications
| Application |
Dilution |
Notes |
| ELISA |
1:5000-1:10000 |
|
| IHC-P |
1:500-1:2000 |
|
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) Images
Immunochemical staining of mouse CEACAM1 in mouse kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Immunochemical staining of mouse CEACAM1 in mouse intestine with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-CEACAM1 Antibody Alternative Names
Anti-bb-1 Antibody;Anti-Bgp Antibody;Anti-Bgp1 Antibody;Anti-C-CAM Antibody;Anti-Cc1 Antibody;Anti-CD66a Antibody;Anti-Cea-1 Antibody;Anti-Cea-7 Antibody;Anti-Cea1 Antibody;Anti-Cea7 Antibody;Anti-Hv-2 Antibody;Anti-Hv2 Antibody;Anti-mCEA1 Antibody;Anti-Mhv-1 Antibody;Anti-MHVR Antibody;Anti-MHVR1 Antibody;Anti-mmCGM1 Antibody;Anti-mmCGM1a Antibody;Anti-mmCGM2 Antibody
CEACAM1 Background Information
The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.
Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: IHC Antibodies Immune Checkpoint Detection: ICC Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets Co-inhibitory Immune Checkpoint Targets
Immunotherapy Cancer Immunotherapy Targeted Therapy
Full Name
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
References
Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
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