Anti-CEACAM1 Antibody

Cat: 10822-RP04
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Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CEACAM1 Antibody
Validated applications
WB,ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CEACAM1
Immunogen
Recombinant Human CEACAM1 protein (Catalog#10822-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CEACAM1 extracellular domain (rh CEACAM1; Catalog#10822-H08H; NP_001020083.1; Met 1-Gly 428). CEACAM1 specific IgG was purified by human CEACAM1 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CEACAM1 Antibody (Rabbit Polyclonal antibody) Images
Human CEACAM‑1/CD66a Western blot (WB) 13287

Anti-CEACAM1 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:58 kDa

Observed band size:100 kDa

(We are unsure as to the identity of these extra bands.)

Human CEACAM‑1/CD66a Immunohistochemistry(IHC) 17334
Immunochemical staining of human CEACAM1 in human colon carcinoma with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Anti-CEACAM1 Antibody Alternative Names
Anti-BGP Antibody;Anti-BGP1 Antibody;Anti-BGPI Antibody;Anti-CD66a Antibody;Anti-CEACAM‑1 Antibody
CEACAM1 Background Information

The carcinoembryonic-antigen-related cell-adhesion molecule (CEACAM) family of proteins has been implicated in various intercellular-adhesion and intracellular-signalling-mediated effects that govern the growth and differentiation of normal and cancerous cells. CEACAM1, also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. The highly glycosylated CEACAM1 contains one N-terminal V-type Ig-like domain and three C2-type Ig-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. CEACAM1 is a surface glycoprotein expressed on various blood cells, epithelial cells, and vascular cells. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

Immune Checkpoint
Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: ICC Antibodies   Immune Checkpoint Detection: FCM Antibodies   Immune Checkpoint Detection: WB Antibodies
Immune Checkpoint Proteins
Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
References
  • Gray-Owen SD, et al. (2006) CEACAM1: contact-dependent control of immunity. Nat Rev Immunol. 6(6): 433-46.
  • Gu A, et al. (2009) Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture. Exp Cell Res. 315(10): 1668-82.
  • Wong C, et al. (2009) CEACAM1 negatively regulates platelet-collagen interactions and thrombus growth in vitro and in vivo. Blood. 113(8): 1818-28.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CEACAM1 Antibody Rabbit Polyclonal ELISA,IHC-P 80224-T16
    Anti-CEACAM1 Antibody Mouse Monoclonal FCM 80224-MM03
    Anti-CEACAM1 Antibody Rabbit Polyclonal ELISA 80224-RP01
    Anti-CEACAM1 Antibody Mouse Monoclonal ELISA 80224-MM05
    Anti-CEACAM1 Antibody (APC) Mouse Monoclonal FCM 80224-MM03-A
    Anti-CEACAM1 Antibody (PE) Mouse Monoclonal FCM 80224-MM03-P
    Anti-CEACAM1 Antibody Rabbit Monoclonal ELISA 50571-R025
    Anti-CEACAM1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 50571-R117
    Anti-CEACAM1 Antibody Rabbit Polyclonal ELISA 50571-RP01
    Anti-CEACAM1 Antibody (PE) Rabbit Monoclonal FCM 50571-R117-P
    Anti-CEACAM1 Antibody (FITC) Rabbit Monoclonal FCM 50571-R117-F
    Anti-CEACAM1 Antibody (APC) Rabbit Monoclonal FCM 50571-R117-A
    Anti-CEACAM1 Antibody (PerCP) Rabbit Monoclonal FCM 50571-R117-C
    Anti-CEACAM1 Antibody Rabbit Polyclonal ELISA,IHC-P,IHC-Fr 50571-RP02
    Anti-CEACAM1 Antibody Rabbit Monoclonal IHC-P,IHC-Fr 50571-R030
    Anti-CEACAM1 Antibody Rabbit Monoclonal ELISA(Cap) 10822-R003
    Anti-CEACAM1 Antibody (APC) Rabbit Monoclonal FCM 10822-R103-A
    Anti-CEACAM1 Antibody Mouse Monoclonal ELISA,ELISA(Det),IHC-P,FCM 10822-MM02
    Anti-CEACAM1 Antibody (PE) Rabbit Monoclonal FCM 10822-R103-P
    Anti-CEACAM1 Antibody Rabbit Polyclonal WB,ELISA 10822-RP01
    Anti-CEACAM1 Antibody Rabbit Monoclonal ELISA 10822-R006
    Anti-CEACAM1 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 10822-R103
    Anti-CEACAM1 Antibody (APC) Mouse Monoclonal FCM 10822-MM02-A
    Anti-CEACAM1 Antibody (PE) Mouse Monoclonal FCM 10822-MM02-P
    Anti-CEACAM1 Antibody (FITC) Mouse Monoclonal FCM 10822-MM02-F
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