Anti-CDO Antibody

Cat: 11965-RP02

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Anti-CDO Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CDO Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CDO
Recombinant Human CDON protein (Catalog#11965-H08H)
Produced in rabbits immunized with purified, recombinant Human CDON (rh CDON; Catalog#11965-H08H; AAI14436.1; Met 1-Asp 963). CDON specific IgG was purified by Human CDON affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CDO Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CDO Antibody Alternative Names
Anti-CDO Antibody;Anti-CDON1 Antibody;Anti-HPE11 Antibody;Anti-ORCAM Antibody
CDO Background Information

Cell adhesion molecule-related, down-regulated by oncogenes (CDON), also known as CDO, is an Ig superfamily member, is a component of a cell surface receptor that positively regulates skeletal myogenesis. Brother of CDO (BOC) is a cell surface receptor that derives its name from the structurally related protein, CDON. They are components of a cell surface receptor that positively regulates myogenesis in vitro. Expression of Cdo and Boc in myoblast cell lines is downregulated by the ras oncogene, and forced re-expression of either Cdo or Boc can override ras-induced inhibition of myogenic differentiation. CDO and BOC play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. CDON binds to Bnip-2 and JLP, scaffold proteins for Cdc42 and p38alpha/beta MAPK, respectively. The Bnip-2/Cdc42 and JLP/p38alpha/beta complexes associate in a CDON-dependent manner, resulting in Bnip-2/Cdc42-dependent p38alpha/beta activation and stimulation of cell differentiation. It is proposed that CDO mediates, at least in part, the effects of cell-cell interactions between muscle precursors that are critical in myogenesis.

Full Name
cell adhesion associated, oncogene regulated
  • Kang JS, et al. (1998) CDO, a robo-related cell surface protein that mediates myogenic differentiation. J Cell Biol. 143(2): 403-13.
  • Wegorzewska M, et al. (2003) Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. Mol Carcinog. 37(1): 1-4.
  • Cole F, et al. (2003) Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon. Curr Biol. 13(5): 411-5.
  • Jehee FS, et al. (2006) Mutational screening of FGFR1, CER1, and CDON in a large cohort of trigonocephalic patients. Cleft Palate Craniofac J. 43(2): 148-51.
  • Kavran JM, et al. (2010) All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J Biol Chem. 285(32): 24584-90.
  • Lu M, et al. (2010) N-cadherin ligation, but not Sonic hedgehog binding, initiates Cdo-dependent p38alpha/beta MAPK signaling in skeletal myoblasts. Proc Natl Acad Sci U S A. 107(9): 4212-7.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CDO Antibody Rabbit Monoclonal ELISA 11965-R076
    Anti-CDO Antibody Rabbit Polyclonal ELISA 11965-RP01
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