CDNF Protein & Antibody (ARMETL1)

Cerebral Dopamine Neurotrophic Factor (ARMET-like protein 1)

CDNF / ARMETL1 Products

CDNF / ARMETL1 Protein, Recombinant

Molecule	Species	Description	Cat. No
CDNF/ARMETL1	Mouse	CDNF/ARMETL1 Protein, Recombinant	50569-M08H

CDNF / ARMETL1 Antibody

Molecule	Application	Description	Cat. No
Mouse CDNF/ARMETL1	WB, ELISA	CDNF/ARMETL1 Antibody, Rabbit PAb	50569-RP01
Mouse CDNF/ARMETL1	WB, ELISA	CDNF/ARMETL1 Antibody, Rabbit PAb (Antigen Affinity Purified)	50569-RP02
Mouse CDNF/ARMETL1	WB, ELISA	CDNF/ARMETL1 Antibody, Rabbit MAb	50569-R091
Mouse CDNF/ARMETL1	WB, ELISA	CDNF/ARMETL1 Antibody, Rabbit MAb	50569-R030

CDNF / ARMETL1 cDNA Clone

Molecule	Species	Description	Cat. No
CDNF/ARMETL1	Mouse	Mus musculus CDNF/ARMETL1 cDNA Clone	MG50569-M

CDNF / ARMETL1 Related Areas

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>CDNF/ARMETL1

CDNF / ARMETL1 Alternative Names

CDNF, ARMETL1 [Homo sapiens]

Cdnf, RP24-129J15.1, 9330140G23, Armetl1, MGC129430 [Mus musculus]

CDNF / ARMETL1 Background

Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.

CDNF / ARMETL1 Related Studies

1. Choi JM, et al. (2011) Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease. Neurosci Lett. 493(3): 97-101.
2. Sun ZP, et al. (2011) Intracellular trafficking and secretion of cerebral dopamine neurotrophic factor in neurosecretory cells. J Neurochem. 117(1): 121-32.
3. Lohoff FW, et al. (2009) Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. Neurosci Lett. 453(3): 199-203.
4. Lindholm P, et al. (2007) Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature. 448(7149): 73-7.