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CDKL2  Protein, Antibody, ELISA Kit, cDNA Clone

CDKL2 Related Area

CDKL2 Related Pathways

    CDKL2 Summary & Protein Information

    CDKL2 Background

    Gene Summary: This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus.
    General information above from NCBI
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
    Domain: The [NKR]KIAxRE motif seems to be a cyclin-binding region.
    Subcellular location: Cytoplasm {ECO:0000269|PubMed:9000130}. Nucleus {ECO:0000269|PubMed:9000130}.
    Tissue specificity: Expressed in testis and kidney, and at lower level in brain and lung. {ECO:0000269|PubMed:9000130}.
    Sequence similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    Cyclin-dependent kinase-like 2 (Cdkl2) is a member of cdc2-related serine / threonine protein kinase family and it is found expressed in various brain regions, including the cerebral cortex, entorinal cortex, hippocampus, amygdala, and dorsal thalamus. The high expression in these brain regions suggests that Cdkl2 may have functions in congnition and emotion processes. Cdkl2 accumulates primarily in the cytoplasm, with lower levels in the nucleus.

    CDKL2 Alternative Name

    P56,KKIAMRE, [homo-sapiens]
    CDKL2,KKIAMRE,P56, [human]
    5330436L21Rik,AI505225,KKIAMRE,Kkm,MGC144031,MGC144032,Cdkl2, [mouse]
    Kkm,KKIAMRE,AI505225,5330436L21Rik, [mus-musculus]

    CDKL2 Related Studies

  • Sassa T, et al. (2003) Postnatal expression of Cdkl2 in mouse brain revealed by LacZ inserted into the Cdkl2 locus. Cell and Tissue Research. 315 (2): 147-56.
  • Rosenblatt J, et al. (1992) Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A. PNAS. 89 (7): 2824-8.
  • Mironov V, et al. (1999) Cyclin-Dependent Kinases and Cell Division in Plants-The Nexus. The Plant Cell. 11 (4): 509-22.
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