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CDK7  Protein, Antibody, ELISA Kit, cDNA Clone

CDK7 Related Area

CDK7 Related Pathways

    CDK7 Summary & Protein Information

    CDK7 Background

    Catalytic activity: ATP + a protein = ADP + a phosphoprotein.; ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
    Enzyme regulation: ENZYME REGULATION: Inactivated by phosphorylation. Repressed by roscovitine (seliciclib, CYC202), R547 (Ro-4584820) and SNS-032 (BMS-387032). The association of p53/TP53 to the CAK complex in response to DNA damage reduces kinase activity toward CDK2 and RNA polymerase II repetitive C-terminal domain (CTD), thus stopping cell cycle progression. The inactivation by roscovitine promotes caspase-mediated apoptosis in leukemic cells. {ECO:0000269|PubMed:19911397, ECO:0000269|PubMed:9840937}.
    Subunit structure: Associates primarily with cyclin-H (CCNH) and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor; this complex is sensitive to UV light. The CAK complex binds to p53/TP53 in response to DNA damage. Interacts with CDK2, SF1/NR5A1, PUF60 and PRKCI. {ECO:0000269|PubMed:10882074, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:16327805, ECO:0000269|PubMed:17373709, ECO:0000269|PubMed:17901130, ECO:0000269|PubMed:9840937, ECO:0000269|PubMed:9852112}.
    Subcellular location: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Note=Colocalizes with PRKCI in the cytoplasm and nucleus. Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides.
    Tissue specificity: Ubiquitous.
    Induction: Repressed by DNA-bound peptides. {ECO:0000269|PubMed:19071173}.
    Post-translational: Phosphorylation of Ser-164 during mitosis inactivates the enzyme. Phosphorylation of Thr-170 is required for activity. Phosphorylated at Ser-164 and Thr-170 by CDK2. {ECO:0000269|PubMed:11113184, ECO:0000269|PubMed:15530371, ECO:0000269|PubMed:9832506}.
    Sequence similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
    General information above from UniProt

    CDK7 Alternative Name

    STK1,CAK1,HCAK,MO15,CDKN7,p39MO15, [homo-sapiens]
    Crk4,Cdkn7,AI323415,AI528512,C230069N13, [mus-musculus]

    CDK7 Related Studies

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