CDK4 Protein

Cyclin-Dependent Kinase 4

CDK4 Products

CDK4 Protein, Recombinant

Molecule	Species	Description	Cat. No
CDK4	Human	CDK4 Protein, Recombinant, With GST Tag	10732-H09B

CDK4 cDNA Clone

Molecule	Species	Description	Cat. No
CDK4	Human	Homo sapiens CDK4 cDNA Clone	HG10732-M
CDK4	Mouse	Mouse CDK4 cDNA Clone / ORF Clone	MG50889-G

CDK4 Related Areas

Cancer>>Cell Cycle>>Cyclin-Dependent Kinase (CDK)>>CDK4

Enzyme>>Protein Kinase>>Intracellular Kinase>>Cyclin-Dependent Kinase (CDK)>>CDK4

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CDK4

CDK4 Alternative Names

CDK4, CMM3, MGC14458, PSK-J3 [Homo sapiens]

Cdk4, Crk3 [Mus musculus]

CDK4 Background

CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. CDK4 has been shown to be mutated in some types of cancer, whilst a chromosomal rearrangement can lead to Cdk6 overexpression in lymphoma, leukemia and melanoma.

CDK4 Related Studies

1. Stepanova L, et al. (1996) Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4. Genes Dev. 10(12):1491-502.
2. Lamphere L, et al. (1997) Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 14(16): 1999-2004.
3. Dai K, et al. (1996) Physical interaction of mammalian CDC37 with CDK4. J Biol Chem. 271(36): 22030-4.
4. Sugimoto M, et al. (1999) Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1. Genes Dev. 13(22):3027-33.