CDK16 (PCTAIRE1)

May play a role in signal transduction cascades in terminally differentiated cells.

CDK16 (PCTAIRE1) Related Areas

Enzyme>>Protein Kinase>>Intracellular Kinase>>Cyclin-Dependent Kinase (CDK)>>CDK16/PCTAIRE1

Signal Transduction>>Protein Kinase>>Intracellular Kinase>>CDK16/PCTAIRE1

CDK16 (PCTAIRE1) Alternative Names

CDK16, PCTAIRE1, FLJ16665, PCTAIRE, PCTGAIRE, PCTK1 [Homo sapiens]

Cdk16, Pctaire1, RP23-394F6.3, Crk5, Pctk1 [Mus musculus]

Summaries for CDK16 (PCTAIRE1)

Entrez Gene summary for CDK16 (PCTAIRE1):

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms.

OMIM - description for CDK16 (PCTAIRE1):

The mechanisms that govern the progression through the eukaryotic cell cycle consist of multiple regulatory processes that control discrete transition points, such as the G0/G1 and G1/S transitions and the entry into mitosis. One of the key components regulating the initiation and passage through mitosis is the serine/threonine-specific protein kinase, p34(cdc2/CDC28); see 116953. There exists an extended gene family encoding a large number of different cdc2-related serine/threonine-specific protein kinases. The PCTAIRE protein kinases comprise a distinct subfamily of these kinases and are so named for the presence of a cysteine-for-serine substitution in the conserved PSTAIRE amino acid motif found in prototypic cdc2 kinases. Three members of this kinase subfamily, PCTAIRE 1-3, were identified in humans (Meyerson et al., 1992), whereas only 2 members were identified in mice, PCTAIRE1 and -3 (Okuda et al., 1992). The 3 PCTAIRE kinases are 65% identical to one another (80% within the catalytic domain). PCTAIRE1 is ubiquitously expressed with the highest levels detected in the brain and testis. Human PCTAIRE cDNAs do not complement yeast cdc28 mutants and show other differences, suggesting that PCTAIRE kinases have different cellular functions from those described for CDC2 (116940).

Wikipedia summary for CDK16 (PCTAIRE1):

The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases.Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation. This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. They also function in embryonic development, physiological responses, and in the nervous and immune system. Abnormal phosphorylation causes many human diseases, including cancer, and drugs that affect phosphorylation can treat those diseases. Protein kinases possess a catalytic subunit which transfers the gamma phosphate from nucleoside triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. These enzymes fall into two broad classes, characterised with respect to substrate specificity: serine/threonine specific and tyrosine specific.

Human CDK16 (PCTAIRE1) Protein General Information

 

• Protein names: Recommended name: Cyclin-dependent kinase 16
• Sequence length: 496 AA.
• Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
• Sequence similarities: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain.
• Subunit structure: Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with YWHAH, YWHAQ and YWHAZ

General information above from UniProt

Function for CDK16 (PCTAIRE1) Protein

UniProtKB:

May play a role in signal transduction cascades in terminally differentiated cells.

Genatlas:

• protein kinase superfamily
• CMGC Ser/Thr protein kinase family
• CDC2/CDKX subfamily
• CDK16 (PCTAIRE1) may be playing a role in signal transduction cascades in terminally differentiated cells

Homology for human CDK16 (PCTAIRE1)

• homolog to cdc2