CDCP1 (Protein | Antibody | cDNA Clone | ELISA Kit)

All CDCP1 reagents are produced in house and quality controlled, including 5 CDCP1 Antibody, 1 CDCP1 ELISA, 15 CDCP1 Gene, 5 CDCP1 Lysate, 5 CDCP1 Protein, 2 CDCP1 qPCR. All CDCP1 reagents are ready to use.

CDCP1 Protein (5)

CDCP1 Antibody (5)

CDCP1 ELISA Kit & Match Antibody ELISA Pair Set (1)

CDCP1 cDNA Clone (15)

BC021099
NM_022842.4

In expression vector

XM_001114659.2

In expression vector

CDCP1 Lysate (5)

CDCP1 Background

CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA42 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

CDCP1 References

  • Conze T, et al.. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci. 996 (1): 222-6.
  • Hooper JD, et al. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene. 22(12): 1783-94.
  • Scherl-Mostageer M, et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene. 20(32):4402-8.