All CDCP1 reagents are produced in house and quality controlled, including 4 CDCP1 Antibody, 1 CDCP1 ELISA, 13 CDCP1 Gene, 5 CDCP1 Lysate, 5 CDCP1 Protein, 2 CDCP1 qPCR. All CDCP1 reagents are ready to use.
Recombinant CDCP1 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-mouse IgG1-Fc, C-human IgG1-Fc.
CDCP1antibodies are validated with different applications, which are ELISA(Cap), ELISA, IHC-P.
CDCP1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CDCP1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
CDCP1ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.