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Human CDCP1 / CD318 Protein (Fc Tag)
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Human CDCP1 / CD318 Protein (Fc Tag) PDF Download

Catalog   Size (Price) Quantity In Stock Operation
13262-H05H  
YES   
 

Protein Production & Purification Service | Recombinant Cytokines & Growth Factors

CUB domain containing protein 1 Protein Datasheet

 

CDCP1 / CD318 Protein Price Inquiry ( Available Sizes )

CDCP1 / CD318 Protein Product Information

Synonym : CDCP1, TRASK
Protein Construction:

A DNA sequence encoding the human CDCP1 (Q9H5V8-3) (Met1-Glu343) was  fused with Fc region of mouse IgG at the C-terminus.

Source: Human
Expression Host: Human Cells

CDCP1 / CD318 Protein QC Testing

Purity: (77.1+20.1) % as determined by SDS-PAGE SDS-PAGE:
SDS-PAGE

CDCP1 / CD318 protein

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
Stability: Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal: Phe 30
Molecular Mass:

The recombinant human CDCP1 /mFc is a disulfide-linked homodimer. The reduced monomer comprises 548 amino acids and has a predicted molecular mass of 61.4 kDa. The apparent molecular mass of the protein is approximately 89-93 in SDS-PAGE under reducing conditions due to glycosylation.

Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.

CDCP1 / CD318 Protein Usage Guide

Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

CDCP1 / CD318 Protein Related Products & Topics

Related Areas:

Cancer >>Cancer Biomarker>>CDCP1

Proteins:

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat No
CDCP1 Human CDCP1 / CD318 Protein, Recombinant 13262-H05H
CDCP1 Mouse CDCP1 Protein, Recombinant 51110-M02H
CDCP1 Mouse CDCP1 Protein, Recombinant 51110-M08H

Antibodies:

CDCP1 / CD318 Protein Description

CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. CDCP1 is a key regulator of EGF/EGFR-induced cell migration. It may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.

References

  1. Conze T. et al., 2003, Ann N Y Acad Sci. 996 (1): 222-6.
  2. Hooper JD. et al., 2003, Oncogene. 22 (12): 1783-94.
  3. Scherl-Mostageer M. et al., 2001, Oncogene. 20 (32): 4402-8.
 
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"