- EGFR Signaling Pathway
- TGF-beta Signaling
- Canonical Wnt Signaling
- non-Canonical Wnt Signaling
- Notch Signaling
- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
CUB domain containing protein 1 Protein Datasheet
CDCP1 / CD318 Protein Price Inquiry ( Available Sizes )
CDCP1 / CD318 Protein Product Information
|Synonym :||CDCP1, TRASK|
A DNA sequence encoding the human CDCP1 (Q9H5V8-3) (Met1-Glu343) was fused with Fc region of mouse IgG at the C-terminus.
|Expression Host:||Human Cells|
CDCP1 / CD318 Protein QC Testing
|Purity:||(77.1+20.1) % as determined by SDS-PAGE||SDS-PAGE:
CDCP1 / CD318 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Phe 30|
The recombinant human CDCP1 /mFc is a disulfide-linked homodimer. The reduced monomer comprises 548 amino acids and has a predicted molecular mass of 61.4 kDa. The apparent molecular mass of the protein is approximately 89-93 in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
CDCP1 / CD318 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
CDCP1 / CD318 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat No|
|CDCP1||Human||CDCP1 / CD318 Protein, Recombinant||13262-H05H|
|CDCP1||Mouse||CDCP1 Protein, Recombinant||51110-M02H|
|CDCP1||Mouse||CDCP1 Protein, Recombinant||51110-M08H|
CDCP1 / CD318 Protein Description
CDCP1 is a transmembrane protein containing three extracellular CUB domains. This protein is found to be overexpressed in colon and lung cancers. Its expression level is correlated with the metastatic ability of carcinoma cells. This protein is located on the cell surface. It has been shown to be tyrosine phosphorylated in a cancer cell line. CDCP1 is a key regulator of EGF/EGFR-induced cell migration. It may be a rational approach to inhibit progression of cancers driven by EGFR signaling including those resistant to anti-EGFR drugs because of activating mutations in the RAS/RAF/MEK/ERK pathway. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.
- Conze T. et al., 2003, Ann N Y Acad Sci. 996 (1): 222-6.
- Hooper JD. et al., 2003, Oncogene. 22 (12): 1783-94.
- Scherl-Mostageer M. et al., 2001, Oncogene. 20 (32): 4402-8.