CDC42 Protein

Cell Division Cycle 42

CDC42 Products

CDC42 Protein, Recombinant

Molecule	Species	Description	Cat. No
CDC42	Human	CDC42 Protein, Recombinant, with GST Tag	10062-H09E

CDC42 cDNA Clone

Molecule	Species	Description	Cat. No
CDC42	Human	Human CDC42 transcript variant 3 cDNA Clone / ORF Clone	HG10062-M

CDC42 Related Areas

Cancer>>Cell Cycle>>CDC42

Stem Cell>>Neural Stem Cell (NSC)>>Neural Crest Stem Cell>>Neural Crest Effector>>CDC42

CDC42 Alternative Names

CDC42, RP1-224A6.5, CDC42Hs, G25K [Homo sapiens]

Cdc42, RP23-246F18.2, AI747189, AU018915 [Mus musculus]

CDC42 Background

CDC42 contains 1 CRIB domain and belongs to the Rho-subfamily. Members of this family regulate signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. CDC42 is a small GTPase and is widely expressed. It is expressed at higher level in T-lymphocytes. It is also highly expressed in CCRF-CEM T-lymphocytes, Jurkat T-lymphocytes, and Raji B-lymphocytes compared (at protein level). CDC42 is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. CDC42 could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. CDC42 cycles between an active GTP-bound and an inactive GDP-bound state. In active state it binds to a variety of effector proteins to regulate cellular responses. CDC42 is involved in epithelial cell polarization processes. It also plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. CDC42 may play a role in early contractile events in phagocytosis in macrophages.

CDC42 Related Studies

et al.
1. Shinjo K, et al. (1990) Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42. Proc Natl Acad Sci. 87(24):9853-7.
2. Munemitsu S, et al. (1990) Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42. Mol Cell Biol. 10(11):5977-82.
3. Walker S J, et al. (2000) Activation of phospholipase D1 by Cdc42 requires the Rho insert region. J Biol Chem. 275(21):15665-8.
4. Low B C, et al. (1999) Tyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42. J Biol Chem. 274(46): 33123-30.
5. Zhang B, et al. (1998) Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA. J Biol Chem. 273(15):8776-82.