All CDC37 reagents are produced in house and quality controlled, including 4 CDC37 Antibody, 30 CDC37 Gene, 3 CDC37 IPKit, 3 CDC37 Lysate, 3 CDC37 Protein, 2 CDC37 qPCR. All CDC37 reagents are ready to use.
Recombinant CDC37 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-cleavage, N-GST, N-GST & His.
CDC37antibodies are validated with different applications, which are WB, ELISA, IHC-P, IP.
CDC37cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each CDC37 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Expression host: Baculovirus-Insect Cells
CDC37 is a protein that is expressed in proliferative zones during embryonic development and in adult tissues, consistent with a positive role in proliferation and is required for cell division in budding yeast. CDC37 is though to play an important role in the establishment of signaling pathways controlling cell proliferation through targeting intrinsically unstable oncoprotein kinases such as Cdk-4, Raf-1, and src to the molecular chaperone Hsp90. Decreased Hsp90 expression can reduce the levels of microtubule-associated protein tau, whose overexpression may induce many diseases. CDC37 is considered as a co-chaperone that is classified to Hsp90's accessory proteins. It has been reported that suppression of Cdc37 destabilized tau, leading to its clearance, whereas cdc37 overexpression preserved tau.Cdc37 was found to co-localize with tau in neuronal cells and to physically interact with tau from human brain. Moreover, Cdc37 levels significantly increased with age.