CD99 Protein

Cluster of Differentiation 99

CD99 Products

CD99 Protein, Recombinant

Molecule	Species	Description	Cat. No
CD99	Mouse	CD99/Fc Protein, Recombinant	50520-M02H

CD99 cDNA Clone

Molecule	Species	Description	Cat. No
CD99	Human	CD99 cDNA Clone / ORF Clone	HG12193-G
CD99	Mouse	Mus musculus CD99 cDNA Clone	MG50520-M
CD99	Rat	CD99 cDNA Clone / ORF Clone	RG80325-G

CD99 Related Areas

Immunology>>Cluster of Differentiation>>CD99

CD99 Alternative Names

CD99, HBA71, MIC2, MIC2X, MIC2Y, MSK5X [Homo sapiens]

Cd99, 1110061M03Rik, 2410026K10Rik, D4, Pilr-l, pilr-1 [Mus musculus]

CD99 Background

The cluster of differentiation (CD) system is commonly used as cell markers in immunophynotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules which associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. CD99 is a transmembrane protein expressed on most hematopoietic cells, endothelial cells and at the borders between confluent cells. CD99 is also found expressed in the development of normal ovary and testis as well as in 25 sex cord-stromal tumors, 7 epithelial neoplasms, and 6 germ cell tumors. CD99 may be a useful marker for sex cord-stromal tumors and that its degree of reactivity correlates with the degree of differentiation in Sertoli-Leydig cell tumors. Additionally, CD99 might aid in distinguishing granulose cell tumors of the ovary from poorly differentiated carcinomas and it has been reported to be a sensitive and specific marker for Ewing's sarcoma and primitive neuroectodermal tumor.

CD99Related Studies

1. Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
2. Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125–35.
3. Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
4. Schenkel AR, et al. (2002) CD99 plays a major role in the migration of monocytes through endothelial junctions. Nature Immunology. 3: 143 – 50.
5. Gordon MD, et al. (1998) CD99, keratin, and vimentin staining of sex cord-stromal tumors, normal ovary, and testis. Mod Pathol. 11 (8): 769-73.