Anti-CD98 Antibody

Cat: 12206-RP02
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All CD98 Reagents
Anti-CD98 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-CD98 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human CD98
Recombinant Human CD98 / SLC3A2 protein (Catalog#12206-H07H)
Produced in rabbits immunized with purified, recombinant Human CD98 / SLC3A2 (rh CD98 / SLC3A2; Catalog#12206-H07H; P08195-1; Arg 206-Ala 630). CD98 / SLC3A2 specific IgG was purified by Human CD98 / SLC3A2 affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-CD98 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:2000  
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  
IP 0.5-1 μL/mg of lysate  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CD98 Antibody (Rabbit Polyclonal antibody) Images
Human CD98/SLC3A2/4F2HC Immunohistochemistry(IHC) 3583
Immunochemical staining of human SLC3A2 in human placenta with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human CD98/SLC3A2/4F2HC Immunohistochemistry(IHC) 3585
Immunochemical staining of human SLC3A2 in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human CD98/SLC3A2/4F2HC Western blot (WB) 13475

Anti-CD98 rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Whole Cell Lysate

Lysates/proteins at 30 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:68 kDa

Observed band size:100 kDa

Human CD98/SLC3A2/4F2HC Immunoprecipitation(IP) 17702

SLC3A2 was immunoprecipitated using:

Lane A:0.5 mg Hela Whole Cell Lysate

2 µL anti-SLC3A2 rabbit polyclonal antibody and 15 μl of 50 % Protein G agarose.

Primary antibody:

Anti-SLC3A2 rabbit polyclonal antibody,at 1:100 dilution

Secondary antibody:

Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution

Developed using the odssey technique.

Performed under reducing conditions.

Predicted band size: 68 kDa

Observed band size: 100 kDa

Anti-CD98 Antibody Alternative Names
Anti-4F2 Antibody;Anti-4F2HC Antibody;Anti-4T2HC Antibody;Anti-CD98 Antibody;Anti-CD98HC Antibody;Anti-MDU1 Antibody;Anti-NACAE Antibody
CD98 Background Information

4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.

Full Name
solute carrier family 3 (amino acid transporter heavy chain), member 2
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  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CD98 Antibody Rabbit Monoclonal ELISA 50813-R021
    Anti-CD98 Antibody Rabbit Monoclonal IHC-P 50813-R048
    Anti-CD98 Antibody Rabbit Polyclonal WB,ELISA,IHC-P 50813-RP02
    Anti-CD98 Antibody Rabbit Polyclonal ELISA 50813-RP01
    Anti-CD98 Antibody Rabbit Monoclonal ELISA 12206-R065
    Anti-CD98 Antibody Rabbit Polyclonal ELISA 12206-RP01
    Anti-CD98 Antibody Rabbit Monoclonal IHC-P 12206-R071
    Anti-CD98 Antibody Mouse Monoclonal IHC-P 12206-MM04
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